Effects of Morus root bark extract and active constituents on blood lipids in hyperlipidemia rats

Journal of Ethnopharmacology
Shi-Zhou QiLong Cui

Abstract

Chinese crude drug Mori Cortex Radicis (the root cortex of Morus species) has been used as a folk medicine to treat hypertension, diabetes, as well as in expectorant, diuretic agents. This investigation aims to study the anti-hyperlipidemia effects of Mori Cortex Radicis (MCR) extracts in hyperlipidemic rat models and the potential therapeutic activities of compounds isolated from the extracts. The effects of MCR on hypolipidemic parameters were investigated using Wistar rats induced by high-lipid emulsion. Sixty healthy Wistar rats were randomly divided into 6 groups: normal group, hyperlipidaemia model group, simvastatin, and high-, medium- and low-dose MCR extracts. After four weeks, body weight, total cholesterol (TC), triglycerides (TG), high and low-density lipoproteins (HDL, LDL), as well as aspartate aminotransferase (AST), alanine aminotransferase (ALT) were measured. To further investigation, four major active compounds were isolated from extracts through high performance liquid chromatography (HPLC) and their diacylglycerol acyltransferase 1 (DGAT1) inhibitory activity was evaluated. MCR dose-dependently reduced serum TC, TG, LDL-C, inhibited the activity of ALT, AST, and increased HDL-C. Furthermore, in vitro bioche...Continue Reading

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Citations

Mar 23, 2017·International Journal of Biological Macromolecules·Yan ZhangHongli Zhou
Jan 16, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Dong Kwon Yang, Dong-Gyu Jo
Jan 17, 2019·International Journal of Molecular Sciences·Elisana Lima RodriguesKarine de Cássia Freitas
Jan 19, 2019·International Journal of Molecular Sciences·Wei ZhuJingkui Tian
Jun 10, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yinyan XuYouhua Xu

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