Effects of mosapride citrate, metoclopramide hydrochloride, lidocaine hydrochloride, and cisapride citrate on equine gastric emptying, small intestinal and caecal motility

Research in Veterinary Science
Koichi OkamuraHisashi Inokuma

Abstract

Although extensive work has been done to elucidate the beneficial and unfavorable effects of gastrointestinal prokinetic agents in humans, little is known on the effects of these agents in horses. In this study, we compared the effects of mosapride, metoclopramide, cisapride, and lidocaine on equine gastric emptying, jejunal and caecal motility and evaluated these agents' adverse drug reactions (ADRs). Seven healthy adult Thoroughbreds. Mosapride 1.0mg/kg and 2.0mg/kg, metoclopramide 0.2mg/kg, and cisapride 1.0mg/kg were dissolved in 100mL distilled water for oral administration. Lidocaine 1.3mg/kg was mixed with 500 mL saline for a 30-min intravenous infusion. Oral administration of 100mL distilled water was used as control. Gastric emptying was evaluated using (13)CO(2) breath test, and jejunal and caecal motility was assessed by electrointestinography. The present study demonstrates that mosapride at doses of 1.0mg/kg and 2.0mg/kg facilitates gastric emptying in horses. Improved jejunal motility was observed following administration of mosapride (1.0mg/kg and 2.0mg/kg), metoclopramide (0.2mg/kg), and cisapride (1.0mg/kg). Similarly, improved caecal motility was observed following administration of mosapride (2.0mg/kg). This ...Continue Reading

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Citations

Jul 8, 2009·The Veterinary Clinics of North America. Equine Practice·Gal Kelmer
Mar 23, 2013·Journal of Gastroenterology and Hepatology·Naoki HosoeToshifumi Hibi
Mar 22, 2014·Equine Veterinary Journal·L C Sanchez, S A Robertson
Mar 1, 2012·World Journal of Gastrointestinal Pathophysiology·María Raquel Huerta-FrancoIsmael Morales-Mata
Aug 27, 2015·World Journal of Gastroenterology : WJG·Shi-Yi WangBin Lv

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