Effects of motor cortical stimulation on the excitability of contralateral motor and sensory cortices

Experimental Brain Research
Hitoshi MochizukiYoshikazu Ugawa

Abstract

Single pulses of transcranial magnetic stimulation (TMS) were applied to the right hemisphere over either the hand sensory area, the hand motor area (M1), ventral premotor area (vPM), dorsolateral prefrontal cortex, or 10 cm away from head (sham stimulation) in order to test the effect on motor evoked potentials (MEPs) elicited by single pulse TMS or transcranial electrical stimulus (TES) over the left M1 or the somatosensory evoked potential (SEP) elicited by an electrical stimulus to the right median nerve. The interstimulus intervals (ISIs) for MEP experiments were 50, 100, 150, 200, 300 and 400 ms, with those for SEP experiments being adjusted for the impulse conduction time from the wrist to the cortex. TMS over the right M1 reduced MEPs elicited by TMS of the left motor cortex at ISIs of 50-150 ms, whereas MEPs produced by TES were unaffected. TMS over M1 and vPM facilitated the contralateral cortical median nerve SEPs at an ISI of 100-200 ms, whereas it had no effect on tibial nerve SEPs or paired median nerve stimulation SEP. Based on these results, we conclude that at around 150-ms intervals, TMS over the motor areas (M1 and vPM) reduces the excitability of the contralateral motor area. This has a secondary effect of e...Continue Reading

Citations

Feb 26, 2009·Experimental Brain Research·Rozaliya BikmullinaVadim V Nikulin
Oct 2, 2004·The Journal of Physiology·Hitoshi MochizukiJohn C Rothwell
Mar 27, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Seiko IshikawaJohn C Rothwell
Feb 20, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Masashi HamadaYoshikazu Ugawa
Jul 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurLuis Garcia-Larrea
Sep 16, 2016·Frontiers in Human Neuroscience·Yasuyuki IwataKoichi Hiraoka
Mar 5, 2020·Journal of Neurophysiology·Boris TouvykineNuma Dancause

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