Jul 4, 1989

Effects of MPP+ on the release of serotonin and 5-hydroxyindoleacetic acid from rat striatum in vivo

European Journal of Pharmacology
H Miyake, C C Chiueh


A procedure utilizing brain dialysis was employed to investigate the effects of 1-methyl-4-phenylpyridinium ion (MPP+), the major metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), on the in vivo release of 5-hydroxytryptamine (5-HT) from the rat striatum. MPP+ (10(-5)-10(-2) M) was administered through the microdialysis probe and dialysates were collected and assayed for monoamines and their metabolites by a high performance liquid chromatography coupled with an electrochemical detector (HPLC-EC). In addition to a dopamine (DA) releasing action, MPP+ caused a cumulatively dose-dependent increase in the release of 5-HT while concomitantly producing a decrease in the efflux of 5-hydroxyindoleacetic acid (5-HIAA). This MPP+-induced increase in the 5-HT release, may play an important role in the acute 5-HT syndrome seen in animals after MPTP.

Mentioned in this Paper

Homovanillic Acid
Dialysis Solutions
Serotonin Measurement
August Rats
MPZ gene
Lentiform Nucleus Structure
3,4-Dihydroxyphenylacetic Acid, Monosodium Salt

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