Effects of MPP+ on the release of serotonin and 5-hydroxyindoleacetic acid from rat striatum in vivo.

European Journal of Pharmacology
H Miyake, C C Chiueh

Abstract

A procedure utilizing brain dialysis was employed to investigate the effects of 1-methyl-4-phenylpyridinium ion (MPP+), the major metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), on the in vivo release of 5-hydroxytryptamine (5-HT) from the rat striatum. MPP+ (10(-5)-10(-2) M) was administered through the microdialysis probe and dialysates were collected and assayed for monoamines and their metabolites by a high performance liquid chromatography coupled with an electrochemical detector (HPLC-EC). In addition to a dopamine (DA) releasing action, MPP+ caused a cumulatively dose-dependent increase in the release of 5-HT while concomitantly producing a decrease in the efflux of 5-hydroxyindoleacetic acid (5-HIAA). This MPP+-induced increase in the 5-HT release, may play an important role in the acute 5-HT syndrome seen in animals after MPTP.

References

Dec 29, 1986·Life Sciences·L HernandezB G Hoebel

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Citations

Nov 21, 2000·Journal of Neuroscience Methods·L ZimmerS Chalon
Jul 1, 1997·The Journal of Pharmacy and Pharmacology·T Obata
Oct 3, 2009·Journal of Pineal Research·Anupom Borah, Kochupurackal P Mohanakumar
Jul 11, 2006·Journal of Chemical Neuroanatomy·Rebecca BanerjeeKochupurackal P Mohanakumar
Mar 10, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·T Obata, Y Yamanaka
Feb 8, 2006·Journal of Neural Transmission·T Obata
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei ZhangBin Liu
Nov 17, 1994·Annals of the New York Academy of Sciences·C C ChiuehD L Murphy
Dec 29, 1989·Biochemical and Biophysical Research Communications·S M LiangC C Chiueh

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