Effects of mu- and kappa-opioid receptors on postoperative ileus in rats

European Journal of Pharmacology
B Y De WinterP A Pelckmans

Abstract

In a rat model of postoperative ileus, induced by abdominal surgery, we investigated the effect of mu- and kappa-opioid receptors. Different degrees of inhibition of the gastrointestinal transit, measured by the migration of Evans blue, were achieved by skin incision, laparotomy or laparotomy plus manipulation of the gut. Morphine (1 mg/kg), a preferential mu-opioid receptor agonist, significantly inhibited the transit after skin incision, while the transit after the laparotomy with or without manipulation was not significantly affected. Fedotozine (5 mg/kg), a peripheral kappa-opioid receptor agonist, enhanced the transit after laparotomy plus manipulation, while naloxone (1 mg/kg), a non-specific opioid receptor antagonist, further inhibited the transit after laparotomy plus manipulation. Naloxone and fedotozine alone had no effect on the transit after skin incision or laparotomy without manipulation. However, naloxone prevented the effect of morphine on the transit after skin incision and of fedotozine on the laparotomy plus manipulation. These results support a role for peripheral kappa-opioid receptors in the pathogenesis of postoperative ileus induced by abdominal surgery.

References

Jan 1, 1979·Scandinavian Journal of Gastroenterology·H AbrahamssonK Glise
Aug 1, 1978·The American Journal of Digestive Diseases·L BuenoY Ruckebusch
Jan 1, 1990·Digestive Diseases and Sciences·E H Livingston, E P Passaro
Jan 1, 1980·Scandinavian Journal of Gastroenterology·H Glise, H Abrahamsson
Jan 1, 1993·Anesthesia and Analgesia·C Stein
Feb 1, 1996·Acta Anaesthesiologica Scandinavica·S E ThörnJ Säwe
Feb 1, 1997·British Journal of Pharmacology·B Y De WinterP A Pelckmans

❮ Previous
Next ❯

Citations

Feb 24, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J LeeM J Bishop
Nov 23, 2006·Intensive Care Medicine·Sonja FruhwaldHelfried Metzler
Nov 30, 2000·Current Treatment Options in Gastroenterology·E M Quigley
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Nov 25, 2000·The British Journal of Surgery·K Holte, H Kehlet
Feb 11, 2005·Current Opinion in Gastroenterology·Robin C Spiller
Jun 9, 2005·Critical Care Medicine·Beverley A MooreAnthony J Bauer
Nov 15, 2000·Gut·H Kehlet
Apr 20, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B BonazC Feuerstein
Feb 13, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J SchmidtA J Bauer
Sep 11, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G J Sanger, B R Tuladhar
Sep 11, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A J Bauer, G E Boeckxstaens
Jan 25, 2007·Expert Opinion on Investigational Drugs·Peter Holzer
Dec 16, 2000·Expert Opinion on Investigational Drugs·M Delvaux
Dec 19, 2008·Expert Review of Gastroenterology & Hepatology·Wouter J de Jonge, David R Greaves
Feb 12, 2011·Expert Review of Gastroenterology & Hepatology·Daniel P HolschneiderEmeran A Mayer
Nov 18, 2005·Life Sciences·A C GrayP J White
Jul 28, 2004·Current Surgery·James C Nunley, Gregory P FitzHarris
Jul 20, 2006·World Journal of Surgery·Peter Mattei, John L Rombeau
Jul 6, 2005·British Journal of Pharmacology·Frans O TheGuy E Boeckxstaens
May 16, 2006·Digestive Diseases·Sangeeta R Mehendale, Chun-Su Yuan
Dec 24, 2004·Anesthesia and Analgesia·Michael G Mythen
Oct 19, 2002·Current Opinion in Critical Care·Anthony J BauerJörg C Kalff
Sep 30, 2020·Anesthesia Progress·Norika KatagiriKanta Kido
Aug 22, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Camilleri
Jul 11, 2018·World Journal of Clinical Cases·Roberto Anaya-PradoMarian Eliza Izaguirre-Pérez
Aug 4, 2011·Equine Veterinary Journal. Supplement·C Hopster-IversenA K Rötting
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian Behm, Neil Stollman
Mar 26, 2009·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Yu-Fang LiuRick Sai-Chuen Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.