Effects of mu opioid agonists alone and in combination with cocaine and D-amphetamine in rhesus monkeys trained to discriminate cocaine

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
S S NegusN K Mello

Abstract

Psychomotor stimulants and mu opioid agonists are often used together by polydrug abusers, and it has been suggested that this form of polydrug abuse may result from the ability of stimulants and mu agonists to enhance each other's abuse-related effects. To investigate this possibility, the present study examined stimulant-opioid interactions in rhesus monkeys trained to discriminate cocaine. Specifically, the effects of the mu opioid agonists heroin, alfentanil, fentanyl, and morphine administered alone or in combination with cocaine or d-amphetamine were examined in five monkeys trained to discriminate 0.4 mg/kg cocaine (IM) from saline in a two-lever, food-reinforced drug discrimination procedure. When administered alone, the rapid onset mu agonists heroin (0.032-0.32 mg/kg) and alfentanil (0.01-0.1 mg/kg) substituted completely for cocaine in three of five monkeys but produced primarily saline-appropriate responding in the other two monkeys. The slower onset mu agonists fentanyl (0.0056-0.056 mg/kg) and morphine (0.56-10 mg/kg) substituted for cocaine in only one of five monkeys. When administered as pretreatments to cocaine, morphine and fentanyl increased levels of cocaine-appropriate responding produced by low doses of c...Continue Reading

Citations

Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·M B GatchN K Mello
Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·K R Powell, S G Holtzman
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Dec 8, 2009·The Journal of Pharmacology and Experimental Therapeutics·Donna M PlattRoger D Spealman
Nov 26, 2008·European Journal of Pharmacology·S Stevens NegusKenner C Rice
Jan 26, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Guobin BaoGang Pei
Nov 20, 2004·The Journal of Pharmacology and Experimental Therapeutics·James K RowlettRoger D Spealman
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·S Stevens Negus, Nancy K Mello
Oct 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Lance R McMahonCharles P France
Feb 27, 2004·The Journal of Pharmacology and Experimental Therapeutics·James K RowlettRoger D Spealman
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Carrie A BowenS Stevens Negus
Dec 7, 2018·Neuropsychopharmacology Reports·Kazuki FujiiKeizo Takao

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