Effects of multiple inherited and acquired thrombophilia on outcomes of in-vitro fertilization

Thrombosis Research
Marcello Di NisioEttore Porreca

Abstract

The effects of multiple inherited and acquired thrombophilic defects on the outcome of in-vitro fertilization (IVF) remain unexplored. The aim of this study was to evaluate the association between multiple thrombophilia and clinical outcomes in a large prospective cohort of women undergoing IVF. Consecutive women scheduled for IVF were eligible. The primary study outcome was live birth. Secondary outcomes included spontaneous abortion, clinical pregnancy, and symptomatic venous thromboembolism. 687 women with a mean age of 34.6 (±3.2) years were included. Overall, 22 women (3.2%) had two or more thrombophilic defects. The probability of live birth was not statistically significantly different between women with ≥2 thrombophilia (odds ratio [OR] 0.62; 95% confidence interval [CI], 0.18 to 2.11) or ≥1 thrombophilia (OR 0.67;95% CI, 0.41 to 1.09) and women without any thrombophilia. None of the individual inherited thrombophilia nor positivity to antiphospholipid antibodies or lupus anticoagulant were associated with live birth. Single positivity for lupus anticoagulant carried a more than threefold higher risk of abortion (OR 3.74; 95% CI, 1.30 to 10.75). There were no statistically significant associations between individual or ...Continue Reading

Citations

Dec 13, 2019·Lupus·G El HasbaniI Uthman
Feb 23, 2019·International Journal of Molecular Sciences·Mara SimopoulouMichael Koutsilieris
Jan 12, 2021·Frontiers in Endocrinology·Matteo CandeloroEttore Porreca
Dec 4, 2019·Best Practice & Research. Clinical Obstetrics & Gynaecology·Michael D Lockshin

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