Effects of Multivitamin Supplements on Cognitive Function, Serum Homocysteine Level, and Depression of Korean Older Adults With Mild Cognitive Impairment in Care Facilities

Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing
Hye Kyung LeeSohyune R Sok

Abstract

To examine effects of multivitamin supplements on cognitive function, serum homocysteine level, and depression of Korean older adults with mild cognitive impairment (MCI) in care facilities. A quasi-experimental pretest-posttest control group design was employed. Forty-eight adults 65 years of age and older with MCI (experimental, n = 24; control, n = 24) who were living in care facilities in Gyeong-gi-do, Korea, were recruited. Multivitamin supplements as experimental treatment consisted of vitamin B6, B12, and folic acid. Multivitamin supplements were taken at a dosage of one pill every day for 12 weeks through the oral route. Measures were Mini Mental State Examination-Korean, serum homocysteine level, and Geriatric Depression Scale Short Form Korea Version. Collected data were analyzed using SPSS version 21.0 statistical software (SPSS Inc., Chicago, IL, USA). There were significant effects of multivitamin supplements on cognitive function (F = 3.624, p = .021), serum homocysteine level (F = 6.974, p = .001), and depression (F = 10.849, p = .001). Multivitamin supplements increased cognitive function, and decreased serum homocysteine level and depression of Korean older adults with MCI in care facilities. Multivitamin suppl...Continue Reading

References

Feb 1, 1992·European Journal of Clinical Investigation·A AnderssonB Hultberg
Nov 15, 1995·JAMA : the Journal of the American Medical Association·O NygårdG Kvåle
Dec 1, 1994·Journal of Internal Medicine·L BrattströmB Hultberg
Mar 1, 1997·The American Journal of Psychiatry·M FavaT Bottiglieri
Jan 5, 2000·The American Journal of Psychiatry·R E RobertsW J Strawbridge
Apr 4, 2000·Neurology·Z GuoL A Farrer
Jul 17, 2001·Dementia and Geriatric Cognitive Disorders·A McCaddonC Wilkinson
Jul 23, 2002·Journal of the American Geriatrics Society·Robert StewartRoy Sherwood
Jan 28, 2003·European Journal of Clinical Nutrition·D ShaharD Fraser
Feb 26, 2003·The American Journal of Clinical Nutrition·Giovanni RavagliaErminia Mariani
Jul 10, 2003·Lancet Neurology·Martha Savaria Morris
Dec 16, 2003·Journal of Neurology·Luigi TrojanoUNKNOWN Congestive Heart Failure Italian Study Investigators
Jan 8, 2004·Clinical Chemistry·Rima ObeidWolfgang Herrmann
Jun 23, 2004·Archives of Gerontology and Geriatrics. Supplement·M GallucciA Vianello
Oct 13, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Angeles Garcia, Katherine Zanibbi
Apr 29, 2005·Psychological Medicine·Perminder S SachdevAnthony F Jorm
Jun 3, 2005·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Rossana Salerno-Kennedy, Kevin D Cashman
Mar 15, 2006·The New England Journal of Medicine·Eva LonnUNKNOWN Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators
Apr 25, 2006·Lancet·Serge GauthierUNKNOWN International Psychogeriatric Association Expert Conference on mild cognitive impairment
Jun 20, 2006·Lancet·Peter Whitehouse, Henry Brodaty
Apr 25, 2007·International Journal of Aging & Human Development·Jeffrey Dean Webster, Odette Gould
Jun 15, 2007·Aging & Mental Health·Ernst BohlmeijerFilip Smit
Aug 20, 2008·Food and Nutrition Bulletin·Jacob Selhub
Aug 21, 2008·Geriatrics & Gerontology International·Shinji IizakaHiromi Sanada
Oct 7, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Teruhiko KoikeAkihisa Iguchi
Jul 23, 2009·The British Journal of Nutrition·Christine SmolinerMatthias Pirlich
Sep 18, 2010·Journal of Alzheimer's Disease : JAD·Alan D DangourBruno Vellas
May 4, 2012·Expert Review of Neurotherapeutics·Ponnusamy Subramaniam, Bob Woods
Apr 22, 2015·International nursing review·S R Sok

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Citations

Jan 27, 2018·Indian Journal of Clinical Biochemistry : IJCB·Seema BhargavaSangeeta Choudhury
Feb 26, 2020·International Journal of Molecular Sciences·Elena AzziniAngela Polito
Oct 26, 2018·Journal of Gerontological Nursing·Min Kyung Gu, Sohyune R Sok
Oct 21, 2020·International Journal of Environmental Research and Public Health·Sohyune R SokYoungmi Cho

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