PMID: 3762139Sep 1, 1986Paper

Effects of muramyl dipeptide and clindamycin in a murine abdominal abscess model

The Journal of Surgical Research
W G CheadleH C Polk

Abstract

Peritonitis and subsequent local and remote complications are an important source of morbidity and mortality, which persist despite the best available treatment. Reasonable therapeutic efforts, therefore, have included stimulation of host defenses with immune adjuvants, recently typified by muramyl dipeptide (MDP). Murine abdominal abscesses were created by intraperitoneal injection of Bacteroides fragilis and autoclaved fecal suspensions, and the effects of MDP and clindamycin on these abscesses were evaluated. At 10(4) colony-forming units (CFU) per milliliter of Bacteroides fragilis, intraperitoneal clindamycin was effective in reducing both the incidence of abscess formation as well as the number of abscesses per mouse as compared with controls at doses of 5 mg/kg and 2 mg/kg (P less than 0.01). The effect was more significant when the drug was given 30 min prior than when given after injection of organisms (P less than 0.02). At 10(7) and 10(8) CFU/ml, pretreatment with MDP increased abscess formation (P less than 0.05, P less than 0.01), an effect that was obscured by clindamycin administration, which decreased number of abscesses from controls irrespective of pretreatment with MDP. Abscesses were present on the third day...Continue Reading

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·L ChedidE Lederer
Aug 1, 1978·European Journal of Immunology·M FevrierP Liacopoulos
Nov 1, 1977·Annals of Surgery·P F LawrenceT C King
May 1, 1975·Annals of Surgery·H H StoneC E Geheber
Sep 1, 1975·The Journal of Infectious Diseases·W M WeinsteinS L Gorbach
Jan 1, 1986·Archives of Surgery·G L BrownH C Polk
Aug 19, 1974·Biochemical and Biophysical Research Communications·F EllouzE Lederer
May 23, 1974·The New England Journal of Medicine·S L Gorbach, J G Bartlett
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Jan 1, 1982·Annual Review of Medicine·D F Zaleznik, D L Kasper
Jun 1, 1980·The Journal of Surgical Research·D E FryR D Rink

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