Effects of muscarinic receptor antagonism upon two forms of stress-induced analgesia

Pharmacology, Biochemistry, and Behavior
E SperberR J Bodnar

Abstract

The present study assessed in rats the effects of muscarinic receptor antagonism upon analgesia induced by cold-water swims (CWS: 2 degrees C for 3.5 min) and 2-deoxy-D-glucose (2DG: 600 mg/kg). First, CWS analgesia was significantly reduced 30 min after the swim by scopolamine (0.01 and 0.1 mg/kg) and methylscopolamine (10 mg/kg) pretreatment, and was eliminated 60 min after the swim by scopolamine (0.01-10 mg/kg) and methylscopolamine (1,10 mg/kg) pretreatment. In contrast, scopolamine potentiated CWS hypothermia. Second, while scopolamine (1 mg/kg) and methylscopolamine (1,10 mg/kg) pretreatment prolonged 2DG analgesia, both antagonists dose-dependently reduced 2DG hyperphagia. Third, the changes in analgesic and hypothermic stress responses were not due to baseline shifts in jump thresholds or body temperatures. However the dose-dependent reductions by scopolamine and methylscopolamine in baseline food intake and 2DG hyperphagia were significantly correlated. Fourth, the dose-dependent reduction by scopolamine and methylscopolamine of pilocarpine analgesia differed in pattern from the other analgesic effects, suggesting heterogeneity in muscarinic receptor modulation of different analgesic responses.

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Citations

Jan 1, 1988·Physiology & Behavior·E Lubin, R J Bodnar
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·J M Kiefel, R J Bodnar
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·M C Fisher, R J Bodnar
Mar 1, 1987·Peptides·P D Butler, R J Bodnar
Nov 1, 1987·Peptides·G A OlsonA J Kastin
May 1, 1999·Physiology & Behavior·B Sadowski, M Konarzewski

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