PMID: 7370752Apr 21, 1980Paper

Effects of muscimol and picrotoxin on single unit activity of substantia nigra neurons

Brain Research
B L WaszczakJ R Walters

Abstract

Intravenous administration of the GABA agonist, muscimol, caused dose-dependent increases in the unit activity of substantia nigra pars compacta (dopamine) neurons and an inhibition of nigral pars reticulata cells. The depressant effects of the drug upon reticulata neurons were reversible by subsequent administration of the GABA antagonists, picrotoxin and bicuculline HCl. However, the stimulatory effects of i.v. muscimol upon dopamine neurons were not abolished by these agents. Intravenous administration of picrotoxin alone caused only moderate increases in the activity of dopamine neurons (31% over baseline at 7.0 mg/kg), but markedly stimulated the firing of pars reticulata cells (154% over baseline at 7.0 mg/kg). In spite of the stimulation of dopamine neurons after i.v. muscimol, microiontophoresis of GABA and muscimol could inhibit the firing of both pars compacta and pars reticulata cells, although the reticulata neurons were much more sensitive to the inhibitory actions of these agents than the dopamine neurons. Considered together, these studies suggest that a population of neurons in the substantia nigra pars reticulata have the capacity to be more affected by a major GABA input to the nigra than the pars compacta dop...Continue Reading

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Citations

Jan 1, 1981·Psychopharmacology·A L Gundlach, P M Beart
Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·S WolfarthK H Sontag
Apr 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·L V Devoĭno, I O Beletskaia
Jun 1, 1987·Metabolic Brain Disease·C L Faingold
Jul 11, 1980·European Journal of Pharmacology·B L WaszczakJ R Walters
Aug 22, 1980·European Journal of Pharmacology·B L Waszczak, J R Walters
May 8, 1981·European Journal of Pharmacology·J M PalaciosE D London
Feb 19, 1981·European Journal of Pharmacology·P SoubriéJ Glowinski
Aug 10, 1990·European Journal of Pharmacology·D E Walters, S G Howard
Jan 19, 1993·European Journal of Pharmacology·J ZhangA S Freeman
Nov 3, 1994·European Journal of Pharmacology·J C LiuB L Waszczak

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