Effects of muscimol inactivations of functional domains in motor, premotor, and posterior parietal cortex on complex movements evoked by electrical stimulation

Journal of Neurophysiology
Iwona StepniewskaJon H Kaas

Abstract

Parietal and frontal cortex are central to controlling forelimb movements. We previously showed that movements such as reach, grasp, and defense can be evoked from primary motor (M1), premotor (PMC), and posterior parietal (PPC) cortex when 500-ms trains of electrical pulses are delivered via microelectrodes. Stimulation sites that evoked a specific movement clustered into domains, which shared a topographic pattern in New World monkeys and prosimian galagos. Matched functional domains in parietal and frontal cortex were preferentially interconnected. We reasoned that matched functional domains form parallel networks involved in specific movements. To test the roles of domains in M1, PMC, and PPC, we systematically inactivated with muscimol domains in one region and determined if functional changes occurred in matching domains in other regions. The most common changes were higher current thresholds for stimulation-evoked movements and shorter, not fully developed, trajectories of movements. Inactivations of an M1 functional domain greatly reduced or abolished movements evoked from the matching domains in PMC or PPC, whereas movements evoked from nonmatching domains remained mostly unaffected. In contrast, inactivating PMC or PP...Continue Reading

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Citations

Dec 3, 2015·Trends in Cognitive Sciences·Michael S A Graziano
Jun 24, 2015·The Journal of Comparative Neurology·Jon H Kaas, Iwona Stepniewska
Aug 5, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michel Desmurget, Angela Sirigu
Dec 17, 2014·Neuroscience Research·Sophia BakolaMarcello G P Rosa
Feb 18, 2015·Frontiers in Behavioral Neuroscience·Marco LanzilottoCristina Lucchetti
Mar 19, 2014·Frontiers in Computational Neuroscience·Simon A OverduinEmilio Bizzi
Oct 11, 2008·PloS One·Chiara BegliominiUmberto Castiello
Jan 5, 2018·Proceedings of the National Academy of Sciences of the United States of America·Inaki-Carril MundinanoJames A Bourne
Jul 28, 2017·Neuroinformatics·Kurt G SchillingAdam W Anderson
Oct 9, 2020·The Journal of Comparative Neurology·Chia-Chi LiaoJon H Kaas
Jul 28, 2020·NeuroImage·Robert M FriedmanOmar A Gharbawie
Feb 8, 2021·ILAR Journal·Jon H Kaas
Apr 19, 2021·Cerebral Cortex·I Caprara, P Janssen
Jun 13, 2021·Neuroscience and Biobehavioral Reviews·Julie RoyoMichel Thiebaut de Schotten

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