Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review

International Journal of Epidemiology
Rufaro KashanguraPaul Garner

Abstract

The existing Bacillus Calmette–Guérin (BCG) vaccination provides partial protection against tuberculosis (TB). The modified vaccinia ankara virus-expressing antigen 85A (MVA85A) aims to boost BCG immunity. We evaluated the animal evidence supporting the testing of MVA85A in humans. Our protocol included in vivo preclinical studies of the MVA85A booster with BCG compared with BCG alone, followed by a TB challenge. We used standard methods for systematic review of animal studies, and summarized mortality, measures of pathology and lung bacterial load. The comprehensive literature search was to September 2014. Two independent investigators assessed eligibility and performed data extraction. We assessed study quality and pooled bacteria load using random effect meta-analysis. We included eight studies in 192 animals. Three experiments were in mice, two in guinea pigs, two in macaques and one in calves. Overall, study quality was low with no randomization, baseline comparability not described and blinding not reported. For animal death (including euthanasia due to severe morbidity), studies were underpowered, and overall no benefit demonstrated. No difference was shown for lung pathology measured on an ordinal scale or bacterial loa...Continue Reading

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Citations

Apr 19, 2016·International Journal of Epidemiology·Jane E Ferrie
May 14, 2016·International Journal of Epidemiology·Ann WilliamsGlyn Hewinson
May 14, 2016·International Journal of Epidemiology·Emily SenaPaul Garner
May 14, 2016·International Journal of Epidemiology·Helen McShaneTom Evans
May 14, 2016·International Journal of Epidemiology·Pcl Beverley
Mar 31, 2018·Human Vaccines & Immunotherapeutics·Wenping GongXueqiong Wu
Feb 19, 2019·Expert Review of Vaccines·Alejandra Mantilla GalindoManuel Alfonso Patarroyo
Nov 27, 2018·Current Molecular Pharmacology·Manaf AlMatarFatih Köksal
May 1, 2019·The Cochrane Database of Systematic Reviews·Rufaro KashanguraSamuel Johnson
Jul 15, 2020·PLoS Biology·Nathalie Percie du SertHanno Würbel
Oct 2, 2019·Frontiers in Immunology·Margarida Correia-NevesGunilla Källenius
Mar 23, 2019·Medical Microbiology and Immunology·Andrea C MéndezMargarita Del Val
Jan 11, 2020·Journal of Translational Medicine·Pandora Pound, Merel Ritskes-Hoitinga
Sep 30, 2020·Disease Models & Mechanisms·Laylaa RamosMercedes Gonzalez-Juarrero
Jul 14, 2017·Pneumonia·James A Triccas, Claudio Counoupas
May 26, 2021·Trends in Microbiology·Rupert L Mayer, Francis Impens

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