PMID: 20622479Jul 14, 2010Paper

Effects of mycotoxins on chemiluminescent response and cytokine mRNA expression of bovine neutrophils

The Journal of Veterinary Medical Science
Kenji WadaHajime Nagahata

Abstract

The effects of aflatoxin B₁ (AFB₁), aflatoxin M₁ (AFM₁), deoxynivalenol (DON) and zearalenone (ZEA) on the viability, chemiluminescent (CL) response and expression of cytokine mRNA of bovine neutrophils (PMNs) were evaluated. The opsonized zymosan (OPZ)-stimulated CL response of PMNs was significantly (P < 0.05) decreased by AFB₁ ( > 50 pg/ml), AFM₁ ( > 50 pg/ml) and ZEA (>50 pg/ml). The phorbol myristate acetate (PMA)-stimulated CL response PMNs was significantly (P < 0.05) decreased by AFB₁ (> 0.5 pg/ml), AFM₁ (> 50 pg/ml), ZEA (> 500 pg/ml) and DON ( > 5 pg/ml). Treatment with AFB₁ resulted in reduction in the mRNA expression of interleukin-1β and tumor necrosis factor-α of PMNs stimulated with OPZ and PMA. These results suggest that these four mycotoxins have inhibitory effects on the function of bovine PMNs.

References

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Mar 6, 2008·The Journal of Veterinary Medical Science·Kenji WadaYoshimi Ogata

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