Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in naïve and Aβ-treated female rats

Biochemical Pharmacology
M BoveLuigia Trabace

Abstract

Depression is one of the most common psychiatric diseases and the prevalence of depressive symptoms in women is almost twice compared to men, although the reasons of this gender difference are not fully understood yet. Recently, soluble Aβ1-42 peptide has been receiving great importance in the development of depression, also since depression is highly comorbid with Alzheimer's disease and other neurodegenerative illnesses. Accordingly, we have previously shown that central Aβ injection is able to elicit depressive-like phenotype in male rats. In the present study, we reproduced for the first time the Aβ-induced depressive-like model in female rats, evaluating behavioural and neurochemical outcomes. Moreover, we studied the effect of lifelong exposure to either n-3 PUFA enriched or n-3 PUFA deficient diet, in female rats, both intact and after central Aβ administration. Our results confirmed the Aβ-induced depressive-like profile also in female rats. Moreover, chronic exposure to n-3 PUFA deficient diet led to highly negative alterations in behavioural and neurochemical parameters, while lifelong exposure to n-3 PUFA enriched diet was able to restore the Aβ-induced depressive-like profile in female rats. In conclusion, the Aβ-in...Continue Reading

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Citations

Jun 4, 2019·Frontiers in Pharmacology·Maria Grazia Morgese, Luigia Trabace
Oct 15, 2019·Frontiers in Pharmacology·Corinne JoffreSophie Layé
Jun 3, 2021·Biomolecules·Maria Grazia MorgesePaolo Tucci
Aug 6, 2021·Nutrition Research and Practice·Minjeong Chae, Kyong Park
Mar 23, 2019·Toxicology Letters·Laura Hautrive MilanesiMarilise E Burger
Dec 4, 2021·Journal of Biomolecular Structure & Dynamics·Shivani Gupta, Ashok Kumar Dasmahapatra

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