Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia.

The Journal of Biological Chemistry
Daiying ZuoJoseph H Neale

Abstract

The "glutamate" theory of schizophrenia emerged from the observation that phencyclidine (PCP), an open channel antagonist of the NMDA subtype of glutamate receptor, induces schizophrenia-like behaviors in humans. PCP also induces a complex set of behaviors in animal models of this disorder. PCP also increases glutamate and dopamine release in the medial prefrontal cortex and nucleus accumbens, brain regions associated with expression of psychosis. Increased motor activation is among the PCP-induced behaviors that have been widely validated as models for the characterization of new antipsychotic drugs. The peptide transmitter N-acetylaspartylglutamate (NAAG) activates a group II metabotropic receptor, mGluR3. Polymorphisms in this receptor have been associated with schizophrenia. Inhibitors of glutamate carboxypeptidase II, an enzyme that inactivates NAAG following synaptic release, reduce several behaviors induced by PCP in animal models. This research tested the hypothesis that two structurally distinct NAAG peptidase inhibitors, ZJ43 and 2-(phosphonomethyl)pentane-1,5-dioic acid, would elevate levels of synaptically released NAAG and reduce PCP-induced increases in glutamate and dopamine levels in the medial prefrontal cortex...Continue Reading

References

Apr 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J R MoffettJ H Neale
Aug 1, 1996·Brain Research. Molecular Brain Research·A MakoffP Emson
Jul 1, 1997·Journal of Neurochemistry·B WroblewskaJ H Neale
Dec 14, 1999·The Journal of Comparative Neurology·U V BergerJ T Coyle
Sep 16, 2000·European Journal of Pharmacology·J CartmellD D Schoepp
Feb 13, 2001·The European Journal of Neuroscience·J ZhaoJ H Neale
Aug 7, 2002·European Journal of Pharmacology·Stephen I DeutschJohn Mastropaolo
Aug 15, 2003·Journal of Neurophysiology·Emilio R Garrido SanabriaAsaf Keller
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael F EganDaniel R Weinberger
Dec 13, 2005·Nature Reviews. Drug Discovery·Jia ZhouAlan P Kozikowski
Jan 24, 2007·The European Journal of Neuroscience·Tatsuo YamamotoJoseph H Neale
Sep 11, 2007·Drug Discovery Today·Takashi TsukamotoBarbara S Slusher
Feb 8, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leah J SartoriusBarbara K Lipska
Jul 18, 2008·Journal of Neurochemistry·Peethambaran ArunAryan M A Namboodiri
Jun 27, 2009·Stereotactic and Functional Neurosurgery·Charles B MikellHolly Moore

❮ Previous
Next ❯

Citations

Jun 7, 2014·Pharmacological Reports : PR·Renny AbrahamAnil Shinde
Sep 21, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kohnosuke KinoshitaJun-Ichi Yamaguchi
Jan 24, 2015·Neuroscience and Biobehavioral Reviews·S Andrea WijtenburgLaura M Rowland
Jan 19, 2018·Behavioral Sciences·Giselle Pentón-Rol, Majel Cervantes-Llanos
Oct 12, 2017·The International Journal of Neuropsychopharmacology·Yoshiaki MiyamotoAtsumi Nitta
May 2, 2013·Journal of Neuroscience Research·Prasanth S AriyannurAryan M A Namboodiri
Sep 19, 2012·The Journal of Pharmacology and Experimental Therapeutics·Krystyna M WozniakBarbara S Slusher
Oct 31, 2015·The Journal of Biological Chemistry·Robert S JansenKoen van de Wetering
Mar 19, 2019·Journal of Alzheimer's Disease : JAD·Kristen R HollingerBarbara S Slusher
Dec 2, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Iria Brocos-MosqueraAmaia M Erdozain
Dec 10, 2019·Trends in Cancer·Anne LeCissy Zhang
Oct 17, 2021·Neuroradiology·Yulu SongRichard A E Edden

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here