Effects of N-acetylcysteine and ethyl pyruvate on ischemia-reperfusion injury in experimental electrical burn model

The American Journal of Emergency Medicine
Turkmen SuhaTuredi Süleyman

Abstract

This study was planned as a histopathologic evaluation of the effectiveness of ethyl pyruvate (EP) and N-acetylcysteine (NAC) in reducing electric burn-related organ damage in an experimental model. Four groups of 7 female Wister rats were established. The first was a sham group, the second an electrical burn control group receiving 600 V, the third group received NAC therapy of 20 mg/kg 1 hour after 600 V electrical burn, and the fourth group received 50 mg/kg EP 1 hour after 600 V electrical burn. Heart, kidney, striated muscle, brain, and lung tissues obtained 24 hours postprocedurally were subjected to histopathologic examination, and injury scores were determined. The values determined were then subjected to statistical analysis. Electrical fire caused significant damage in heart, striated muscle, kidney, and brain tissues. A statistically significant decrease in injury scores in total striated muscle and heart tissue was observed in the 2 treatment groups administered NAC or EP compared to the control group (P= .001). Total kidney injury scores among the groups were significantly lower in the NAC and EP groups compared to the control group (P= .002 and P= .001, respectively). Brain injury examination revealed a significan...Continue Reading

References

Jan 1, 1978·Stroke; a Journal of Cerebral Circulation·J R Little
Dec 1, 1992·Burns : Journal of the International Society for Burn Injuries·Y S HuangZ C Yang
Jan 1, 1991·Renal Failure·K L GuptaK S Chugh
Mar 1, 1987·British Heart Journal·P J JensenU Baandrup
Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Fusun TokatliKemal Kutlu
Sep 10, 2005·Journal of Pineal Research·Korhan ErkanliKaan Kirali
Apr 30, 2008·Current Opinion in Anaesthesiology·Mitchell P Fink
Aug 3, 2010·Scandinavian Journal of Medicine & Science in Sports·C H J PinheiroR Curi
Dec 2, 2010·Toxicologic Pathology·Robert H Garman
Jun 23, 2011·Transplantation Proceedings·A DanilovicA C Seguro
Jul 10, 2012·Annals of Plastic Surgery·Erol BenlierAhmet Cemal Aygit
Apr 18, 2014·PloS One·Katharine EakinBarry J Hoffer
Oct 28, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anthony J BastinMark J Griffiths

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Citations

Dec 19, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Selim DemirAhmet Mentese
Feb 10, 2019·Journal of Biomedical Materials Research. Part a·Jinfei HouZhenxing Wang
Jun 12, 2021·International Journal of Nanomedicine·Jian LiuRongrong Wang

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