PMID: 11920607Mar 29, 2002Paper

Effects of N-acetylcysteine in an esophageal carcinogenesis model in rats treated with diethylnitrosamine and diethyldithiocarbamate

International Journal of Cancer. Journal International Du Cancer
R M BalanskyS De Flora

Abstract

Due to the increasing role of esophageal tumors in human cancer pathology, there is need for animal models evaluating the mechanisms of esophageal carcinogenesis and investigating protective factors toward this disease. Several N-nitrosamines have been shown to induce esophageal tumors in rats. We designed a study in BD(6) rats treated with N-diethylnitrosamine (DEN) according to a simple protocol involving weekly i.p. injections of this carcinogen for 8 consecutive weeks. This treatment resulted in a high incidence and multiplicity of liver tumors and in occurrence of preneoplastic lesions and papillomas in the esophagus. Intraperitoneal injections of diethyldithiocarbamate (DEDTC), 4 hr after each DEN injection, i.e., during the period of DEN metabolization, improved survival of rats and did not affect the liver tumor yield but doubled the incidence of esophageal tumors and enhanced 4.9x their multiplicity. Moreover, 15% of rats developed esophageal squamocellular carcinomas. The oral administration of the thiol N-acetyl-L-cysteine (NAC), a precursor and analogue of reduced glutathione, to rats treated with the DEN/DEDTC combination did not change the liver tumor yield but attenuated esophageal carcinogenesis by producing a s...Continue Reading

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Citations

Jan 5, 2011·Investigational New Drugs·Pius MaliakalRiyaz Basha
Sep 18, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Job C TharappelHoward P Glauert
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Jan 1, 2003·World Journal of Gastroenterology : WJG·Jia-He YangMeng-Chao Wu
Mar 27, 2018·Bulletin of Experimental Biology and Medicine·A V ShubinI V Demidyuk

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