Effects of N-acetylcysteine on brain glutamate levels and resting perfusion in schizophrenia.

Psychopharmacology
Grant McQueenAlice Egerton

Abstract

N-Acetylcysteine (NAC) is currently under investigation as an adjunctive treatment for schizophrenia. The therapeutic potential of NAC may involve modulation of brain glutamate function, but its effects on brain glutamate levels in schizophrenia have not been evaluated. The aim of this study was to examine whether a single dose of NAC can alter brain glutamate levels. A secondary aim was to characterise its effects on regional brain perfusion. In a double-blind placebo-controlled crossover study, 19 patients with a diagnosis of schizophrenia underwent two MRI scans, following oral administration of 2400 mg NAC or matching placebo. Proton magnetic resonance spectroscopy was used to investigate the effect of NAC on glutamate and Glx (glutamate plus glutamine) levels scaled to creatine (Cr) in the anterior cingulate cortex (ACC) and in the right caudate nucleus. Pulsed continuous arterial spin labelling was used to assess the effects of NAC on resting cerebral blood flow (rCBF) in the same regions. Relative to the placebo condition, the NAC condition was associated with lower levels of Glx/Cr, in the ACC (P < 0.05), but not in the caudate nucleus. There were no significant differences in CBF in the NAC compared to placebo conditio...Continue Reading

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Citations

Jan 3, 2020·Journal of Psychosocial Nursing and Mental Health Services·Barbara J Limandri
Sep 6, 2019·Psychopharmacology·Alice Egerton
Jan 6, 2021·Schizophrenia Bulletin·Grant McQueenAlice Egerton
Jan 8, 2021·Molecular Neurobiology·G MorrisB K Puri
Nov 13, 2020·Frontiers in Pharmacology·Dennis KätzelDavid M Bannerman
Aug 10, 2020·Neuroscience·T Blanco-AyalaR Schwarcz
Jul 3, 2021·Antioxidants·Micaely Cristina Dos Santos TenórioMarília Oliveira Fonseca Goulart
Aug 15, 2021·Behavioural Brain Research·Cora E SmileyJustin T Gass
Jun 25, 2020·Annals of Nutrition & Metabolism·Sergej M Ostojic

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Clinical Trials Mentioned

NCT02483130

Software Mentioned

SPM
SPSS
Automatic Software for ASL Processing ( ASAP )
LCModel
MATLAB
GE Sage 7
Statistical Mapping

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