Effects of N-acetylcysteine on First-Line Sequential Therapy for Helicobacter pylori Infection: A Randomized Controlled Pilot Trial

Gut and Liver
Hyuk YoonNayoung Kim

Abstract

To evaluate the adjuvant effects of N-acetylcysteine (NAC) on first-line sequential therapy (SQT) for Helicobacter pylori infection. Patients with H. pylori infections were randomly assigned to receive sequential therapy with (SQT+NAC group, n=49) or without (SQT-only group, n=50) NAC. Sequential therapy consisted of rabeprazole 20 mg and amoxicillin 1 g for the first 5 days, followed by rabeprazole 20 mg, clarithromycin 500 mg and metronidazole 500 mg for the remaining 5 days; all drugs were administered twice daily. For the SQT+NAC group, NAC 400 mg bid was added for the first 5 days of sequential therapy. H. pylori eradication was evaluated 4 weeks after the completion of therapy. The eradication rates by intention-to-treat analysis were 58.0% in the SQT-only group and 67.3% in the SQT+NAC group (p=0.336). The eradication rates by per-protocol analysis were 70.0% in the SQT-only group and 80.5% in the SQT+NAC group (p=0.274). Compliance was very good in both groups (SQT only/SQT+NAC groups: 95.2%/100%, p=0.494). There was no significant difference in the adverse event rates between groups (SQT-only/SQT+NAC groups: 26.2%/26.8%, p=0.947). The H. pylorieradication rate was numerically higher in the SQT+NAC group than in the SQT...Continue Reading

References

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Citations

Sep 12, 2017·Helicobacter·Anthony O'ConnorColm O'Morain
Feb 13, 2019·The Cochrane Database of Systematic Reviews·Luís Eduardo S FontesRachel Riera
Aug 22, 2020·Therapeutic Advances in Gastroenterology·Chieh-Chang ChenUNKNOWN and for the Taiwan Gastrointestinal Disease and Helicobacter Consortium
Jul 3, 2021·Antioxidants·Micaely Cristina Dos Santos TenórioMarília Oliveira Fonseca Goulart

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