Effects of N-trimethylchitosan on transcellular and paracellular transcorneal drug transport

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Ylenia ZambitoGiacomo Di Colo

Abstract

The effects of N-trimethylchitosan (TMC) on the transcorneal transport of dexamethasone, taken as a marker of the transcellular penetration route, and of tobramycin, a marker of the paracellular route, were studied by assessing the TMC effect on the intraocular pharmacokinetics of each marker. The drugs were topically applied via erodible inserts (weight, 20 mg; diameter, 6 mm; drug dose, 0.3 mg) based on poly(ethylene oxide), containing 10% w/w medicated TMC microspheres (diameter < 2.5 microm). Before application, drug release and insert erosion kinetics, and release mechanism were studied in vitro. With either drug, introduction of 10% TMC into insert did not substantially alter the release and erosion rates, hence this formulation was apt to isolate the transcorneal penetration enhancing effect of TMC. Ocular pharmacokinetics were determined in the rabbit model. TMC produced significant increases of dexamethasone Cmax (5.69 +/- 0.49 vs. 3.07 +/- 0.31 microg/ml) and AUC (619.3 +/- 32.5 vs. 380.5 +/- 32.0 microg min/ml) in the aqueous with respect to the reference TMC-free insert. On the other hand, TMC was unable to yield tobramycin concentrations in the aqueous exceeding the determination limit (0.5 microg/ml). In conclusio...Continue Reading

Citations

Dec 30, 2008·Journal of Materials Science. Materials in Medicine·V K Mourya, Nazma N Inamdar
Jun 19, 2012·Expert Opinion on Drug Delivery·Priyanka PahujaPravin Pawar
Jul 10, 2012·Expert Opinion on Drug Delivery·Ali Demir Sezer, Erdal Cevher
Jul 24, 2012·International Journal of Pharmaceutics·Régis CocoVéronique Préat
Mar 24, 2010·Journal of Pharmaceutical Sciences·I PepićJ Filipović-Grcić
Feb 23, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ylenia Zambito, Giacomo Di Colo
Feb 26, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ylenia ZambitoGiacomo Di Colo
Aug 31, 2011·Journal of Toxicology·Zacharias E Suntres
Jan 23, 2015·AAPS PharmSciTech·Rathapon AsasutjaritGarnpimol C Ritthidej
Dec 5, 2009·Advanced Drug Delivery Reviews·Maria de la FuenteMaria Jose Alonso
Apr 11, 2017·Advanced Drug Delivery Reviews·Dileep R JanagamTao L Lowe
Mar 20, 2020·Pharmaceutics·Rubén Varela-FernándezFrancisco J Otero-Espinar
Jul 11, 2009·The Journal of International Medical Research·H YangH Cui
Oct 20, 2011·Journal of Liposome Research·Huanlei ChenGuangxi Zhai
Sep 16, 2020·International Journal of Molecular Sciences·Angela FabianoYlenia Zambito

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Ylenia ZambitoGiacomo Di Colo
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Ylenia ZambitoGiacomo Di Colo
© 2021 Meta ULC. All rights reserved