PMID: 3792380Oct 1, 1986

Effects of naloxone on apnoea duration during sleep in infants at risk for SIDS

European Journal of Pediatrics
R HaidmayerT Kenner

Abstract

The effects of intravenous injections of the opiate antagonist naloxone (0.005-0.4 mg/kg body weight) on respiratory pattern, apnoea duration and frequency were investigated in six infants with severe sleep apnoea syndrome. Since several authors found elevated plasma- and CSF-levels of endogenous opioids (endorphines) in infants with sleep apnoea syndrome, we wanted to determine whether the impairment of the control mechanisms of respiration during sleep is due to an effect of endogenous opioids. Independent of the dose, naloxone did not exert any effect on respiratory pattern and occurrence of periodic apnoea. We were unable to prove that endorphines play a major role in pathogenesis of sleep apnoea syndrome in infancy and possibly in sudden infant death syndrome (SIDS). We speculate that elevated levels of endorphines reported by some investigators rather seem to be a consequence of hypoxic stress than a cause for sleep apnoeas.

References

Oct 6, 1977·The New England Journal of Medicine·D C ShannonK O'Connell
May 22, 1975·The New England Journal of Medicine·J V WeilI E Sodal
Jul 1, 1984·American Journal of Perinatology·K SankaranV G Watson
May 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·I R Moss, E M Scarpelli
Jan 1, 1982·Cleveland Clinic Quarterly·J P OrlowskiC W Denko
Dec 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M Pokorski, S Lahiri
Nov 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M M Grunstein, J S Grunstein
Jun 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C E HuntR T Brouillette

Citations

Nov 1, 1987·Peptides·G A OlsonA J Kastin
Oct 1, 1990·The American Review of Respiratory Disease·J E ShookE M Camporesi
Feb 9, 2000·The Journal of Laryngology and Otology·A KalanJ A Wedzicha
Feb 1, 1994·Thorax·Y Khan, J Z Heckmatt
Feb 1, 1991·Thorax·C J GriffithsG J Gibson
Jan 1, 1988·Annals of the New York Academy of Sciences·R Haidmayer, T Kenner

Related Concepts

Tari-Dog
Polychemotherapy
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Respiration
Relative Risk
Sleep, Slow-Wave
Hypersomnia With Periodic Respiration
Sudden Infant Death Syndrome

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