Abstract
We have previously reported the elevation of plasma corticosterone by i.v. naloxone HCl (NX). This work has been extended, with the current study, showing a similar effect with naltrexone HCl (NTX) and that this effect is due to a central action of the drug. Using opiate-naive male rats with chronic i.v. catheters, stereotaxically placed intracerebroventricular (ICV) cannula guides where necessary, and sound-attenuated one-way vision boxes, serial blood samples were obtained from conscious unrestrained animals. NTX (5.0, 10.0, or 20.0 mg/kg i.v.) resulted in a significant increase in plasma corticosterone 15 min following injection. I.V. administration of the methylbromide salts of each drug, which do not cross the blood-brain barrier, did not produce this same elevation in hormone level at several doses (0.4, 1.0, 2.0, 10.0 or 20.0 mg/kg). In contrast, ICV injection of either of the quaternary salts (50 micrograms/10 microliter/animal) resulted in an immediate and sustained rise in plasma corticosterone. Results obtained demonstrate that NTX has a similar effect on plasma corticosterone as NX at the appropriate doses and that the effect is a central rather than a peripheral one.
References
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R E MainsN Ling
Jun 1, 1974·The British Journal of Addiction to Alcohol and Other Drugs·A Saper
Oct 1, 1981·Endocrinology·J R LymangroverM Saffran
Jan 1, 1983·Psychopharmacology·S MousaD Couri
Sep 1, 1981·Neuroendocrinology·A ZanoboniW Zanoboni-Muciaccia
Citations
Jan 1, 1985·Journal of Neural Transmission·D P van Kammen, S C Schulz
Jan 27, 1988·European Journal of Pharmacology·M GuéL Buéno
May 20, 1988·European Journal of Pharmacology·G A CottrellB Bohus
Aug 3, 1987·Life Sciences·V CameronM R MacFarlane
Jan 1, 1988·Life Sciences·M J EstienneG B Rampacek
Nov 1, 1985·Pharmacology, Biochemistry, and Behavior·G J Schaefer, R P Michael
Nov 1, 1986·Pharmacology, Biochemistry, and Behavior·D H MalinS Addington
Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·R M Eisenberg
Jan 1, 1986·Psychoneuroendocrinology·R F McGivernL A Lane
Sep 1, 1989·Brain, Behavior, and Immunity·H B SolvasonV K Ghanta
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·S MarínM P Viveros
Jun 12, 2002·Alcohol·Mirela BudecAleksandra Petković
Aug 1, 1990·Journal of Neuroendocrinology·M I Miguez, M Aldegunde
Mar 1, 1985·Neuropharmacology·D R Brown, L I Goldberg
Mar 26, 2003·The European Journal of Neuroscience·Stephen J GoldEric J Nestler
Mar 19, 2014·Cell Metabolism·Yvonne M Ulrich-Lai, Karen K Ryan
Jun 2, 2015·PloS One·Mads U WernerJørgen B Dahl
Dec 1, 2009·The Journal of Pain : Official Journal of the American Pain Society·Nathaniel KatzJoseph Stauffer
Jan 8, 2008·Hormones and Behavior·Saeed Esmaeili-MahaniAbolhassan Ahmadiani