PMID: 16639868Apr 28, 2006Paper

Effects of naltrexone on the acquisition of alcohol intake in male and female periadolescent and adult alcohol-preferring (P) rats

International Journal of Adolescent Medicine and Health
Helen J K SableW J McBride

Abstract

The objective of this study was to compare the effects of naltrexone (NTX) on the acquisition of alcohol drinking, during periadolescence and adulthood in rats using a rodent model of alcoholism. Periadolescent and adult alcohol-preferring (P) rats of both sexes were given access to water and 15% (v/v) alcohol 24-hr/day for 45 days. Alcohol access started at 1200 hr on post-natal day (PND) 30 for the periadolescent rats and approximately PND 90 for the adult rats. Subcutaneous (SC) injections of NTX (0, 5, 10, 20, and 30 mg/kg) were administered daily between 1600-1700 hr to separate groups of animals during the first 10 days of alcohol access. During the treatment period, differential effects on alcohol intake were seen between periadolescent and adult animals: (a) lower doses of NTX were more effective in the periadolescent than the adult P rats, and (b) greater tolerance to repeated dosing was displayed by adult, compared with periadolescent, rats. By the 20h day of alcohol access there were no significant differences between the NTX dose groups. Additionally, there were no sex of animal differences at the ages tested. These findings indicate that the endogenous opioid system(s) mediating alcohol intake are developmentally p...Continue Reading

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Citations

Feb 22, 2014·Alcohol·Barbara LoiGian Luigi Gessa
Nov 20, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Francheska PerepletchikovaJoan Kaufman
Dec 3, 2009·Alcoholism, Clinical and Experimental Research·Katherine G HillStephen W Kiefer
Jun 12, 2013·Developmental Psychobiology·Melissa MoralesElena I Varlinskaya
Sep 8, 2015·Journal of Psychiatric Research·David T ChauAlan I Green
Feb 26, 2015·Pharmacology, Biochemistry, and Behavior·Catherine F Moore, Wendy J Lynch
Aug 24, 2017·Alcoholism, Clinical and Experimental Research·Bo SöderpalmMia Ericson

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