Effects of natural and chemically synthesized furanones on quorum sensing in Chromobacterium violaceum

BMC Microbiology
Daniel MartinelliReinhard Bachofen

Abstract

Cell to cell signaling systems in Gram-negative bacteria rely on small diffusible molecules such as the N-acylhomoserine lactones (AHL). These compounds are involved in the production of antibiotics, exoenzymes, virulence factors and biofilm formation. They belong to the class of furanone derivatives which are frequently found in nature as pheromones, flavor compounds or secondary metabolites. To obtain more information on the relation between molecular structure and quorum sensing, we tested a variety of natural and chemically synthesized furanones for their ability to interfere with the quorum sensing mechanism using a quantitative bioassay with Chromobacterium violaceum CV026 for antagonistic and agonistic action. We were looking at the following questions: 1) Do these compounds affect growth? 2) Do these compounds activate the quorum sensing system of C. violaceum CV026? 3) Do these compounds inhibit violacein formation induced by the addition of the natural inducer N-hexanoylhomoserine lactone (HHL)? 4) Do these compounds enhance violacein formation in presence of HHL? The naturally produced N-acylhomoserine lactones showed a strong non-linear concentration dependent influence on violacein production in C. violaceum with a...Continue Reading

References

Oct 1, 1986·Archives of Microbiology·A EberhardJ B Schineller
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·A L SchaeferE P Greenberg
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·P D ShawS K Farrand
Nov 7, 1998·Molecular Plant-microbe Interactions : MPMI·C ChaS K Farrand
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·M G SuretteB L Bassler
Mar 6, 1999·Current Opinion in Microbiology·C Fuqua, E P Greenberg
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·M R ParsekE P Greenberg
Aug 31, 1999·Biological Reviews of the Cambridge Philosophical Society·J Colin Slaughter
Sep 10, 1999·Journal of Natural Products·Y W GuoG Cimino
Dec 23, 1999·Current Opinion in Microbiology·B L Bassler
Jan 5, 2000·Bioorganic & Medicinal Chemistry Letters·T KlineL Passador
Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y H DongL H Zhang
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·M R Parsek, E P Greenberg
Nov 23, 2000·Journal of Natural Products·V J MukkuE Helmke
Nov 28, 2000·Journal of Bacteriology·J R Leadbetter, E P Greenberg
Mar 14, 2001·Natural Product Reports·D J Faulkner
Mar 30, 2001·Journal of Natural Products·R RatnayakeP Simmonds
Apr 21, 2001·Journal of Agricultural and Food Chemistry·O SuriyaphanK R Cadwallader
May 17, 2001·Antimicrobial Agents and Chemotherapy·K TatedaC Van Delden
Jun 27, 2001·Applied and Environmental Microbiology·S A BorchardtW F McCoy
Aug 10, 2001·Microbiology·K M Gray, J R Garey
Sep 7, 2001·Annual Review of Microbiology·M B Miller, B L Bassler
Nov 21, 2001·Journal of Agricultural and Food Chemistry·P Guedes De PinhoT A Hogg
Nov 1, 2002·The Lancet Infectious Diseases·Miguel CámaraAndrea Hardman
Feb 6, 2003·The Journal of Biological Chemistry·Zhao-Qing LuoStephen K Farrand
Jun 6, 2003·Applied and Environmental Microbiology·Lars PetersKathrin Riedel
Jun 12, 2003·The Journal of Infection·H Donabedian
Jul 3, 2003·Bioorganic & Medicinal Chemistry·Thomas HjelmgaardJohn Nielsen
Sep 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michiko E Taga, Bonnie L Bassler

❮ Previous
Next ❯

Citations

Sep 12, 2012·Current Microbiology·G Fernandez-BunsterM Martinez
Jan 4, 2013·Current Microbiology·Leandro Reus Rodrigues PerezAfonso Luís Barth
Sep 3, 2011·Biofouling·Sergey DobretsovValerie J Paul
Mar 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Maria Sanchez-ContrerasJ Allan Downie
Sep 8, 2006·Applied and Environmental Microbiology·Maurice NdagijimanaM Elisabetta Guerzoni
Sep 16, 2008·Applied and Environmental Microbiology·Joost C A JanssensSigrid C J De Keersmaecker
Dec 13, 2006·Microbiology and Molecular Biology Reviews : MMBR·Juan E González, Neela D Keshavan
May 11, 2010·Canadian Journal of Microbiology·Pouneh KhalilzadehChristine Roques
Oct 3, 2013·PloS One·Han-Shin Kim, Hee-Deung Park
Jul 24, 2012·Marine Drugs·Laura R HuntLaura D Mydlarz
Jun 6, 2012·Sensors·Li Ying TanKok-Gan Chan
Jun 3, 2014·Marine Drugs·Kaihao Tang, Xiao-Hua Zhang
Jun 4, 2014·Marine Drugs·Christina ViegelmannRuAngelie Edrada-Ebel
Nov 22, 2014·Marine Drugs·Alberto J Martín-RodríguezJosé J Fernández
Jul 15, 2009·Biotechnology and Applied Biochemistry·Sheetal RainaTajalli Keshavarz
Jun 1, 2016·Frontiers in Microbiology·Ramadan HassanShadi Shokralla
Sep 30, 2016·Frontiers in Microbiology·Rodolfo García-Contreras
Sep 15, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Malena E SkogmanAdyary Fallarero
Apr 13, 2017·Journal of Food Protection·Hong Man HouXin Y Liu
Sep 2, 2014·Journal of Applied Microbiology·S A El-MowafyK H Abd El Galil
Mar 13, 2012·International Journal of Molecular Sciences·Alicia Reyes-ArellanoHéctor Salgado-Zamora
Jun 20, 2018·Advanced Materials·Karoline HergetWolfgang Tremel
May 19, 2006·Letters in Applied Microbiology·J H ChooJ-K Hwang
Dec 1, 2010·Environmental Microbiology Reports·Sergey DobretsovValerie J Paul
Jun 24, 2010·Chembiochem : a European Journal of Chemical Biology·Ramiro VílchezIrene Wagner-Döbler
Dec 13, 2006·Cells, Tissues, Organs·A Sbarbati, F Osculati
Dec 12, 2012·Applied Microbiology and Biotechnology·Mohini S Wagh Nee JagtapBharat B Kale
May 28, 2019·Journal of Food Science·Milagros Liseth Castillo RiveraUelinton Manoel Pinto
Mar 21, 2013·Extremophiles : Life Under Extreme Conditions·Nazia MojibAsim K Bej
Jun 11, 2015·Antonie van Leeuwenhoek·Adrian Tandhyka GemiartoCrystale Siew Ying Lim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.