Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice

Journal of Agricultural and Food Chemistry
Li YuanYuyu Shao

Abstract

Isoorientin (ISO) is a natural flavonoid, which is a 6- C-glucoside of luteolin, and has been demonstrated to possess multiple biological properties. In this study, the effects of ISO on the growth performance and gut microbiota of BALB/c mice were investigated. The results showed that ISO could promote food intake and body weight gain, increase the digestibility of crude proteins and utilization of the gross energy, and strengthen antioxidant capacity of mice. We also demonstrated it has no side effects on hepatic and renal functions. Moreover, ISO inhibited the growth of most bacteria in gut microbiota, especially the pathogenic genera of Alistipes, Helicobacter, and Oscillibacter, which could lead to inflammation. Metabolisms of epithelial cell signaling in Helicobacter pylori infection, lipopolysaccharide (LPS) biosynthesis, and LPS biosynthesis proteins in gut microbiota of the control group were more abundant than those in the ISO group, while lipid metabolism and vitamin B6 metabolism were enriched in the ISO group. We found the changes in enrichments of metabolic pathways of the gut microbiota along with the ISO application were positively correlated with the antioxidation, anti-inflammation, and antibiosis. This work p...Continue Reading

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Citations

Jan 30, 2021·Food Research International·Roberto de Paula do NascimentoMário Roberto Maróstica Junior
Mar 26, 2021·Journal of Agricultural and Food Chemistry·Xiao WangZhong Zhang
Apr 16, 2021·The American Journal of Chinese Medicine·Qiao ZhangYuping Tang
May 27, 2021·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Fang-Wei YangFa-Zheng Ren
Aug 7, 2021·Frontiers in Cellular and Infection Microbiology·Andrés GonzálezÁngel Lanas
Oct 2, 2021·Critical Reviews in Food Science and Nutrition·Yinghui LiJunling Shi
Sep 14, 2021·The British Journal of Nutrition·Mostafa Hassan BakyMohamed A Farag

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