Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Tomohiro NabekuraYuichi Uwai

Abstract

Drug efflux transporter P-glycoprotein plays an important role in cancer chemotherapy. The nuclear factor-κB (NF-κB) transcription factors play critical roles in development and progression of cancer. In this study, the effects of natural compounds that can inhibit NF-κB activation on the function of P-glycoprotein were investigated using human MDR1 gene-transfected KB/MDR1 cells. The accumulation of daunorubicin or rhodamine 123, fluorescent substrates of P-glycoprotein, in KB/MDR1 cells increased in the presence of caffeic acid phenetyl ester (CAPE), licochalcone A, anacardic acid, celastrol, xanthohumol, magnolol, and honokiol in a concentration-dependent manner. In contrast, lupeol, zerumbone, thymoquinone, emodin, and anethol had no effects. The ATPase activities of P-glycoprotein were stimulated by CAPE, licochalcone A, anacardic acid, celastrol, xanthohumol, magnolol, and honokiol. Tumor necrosis factor (TNF)-α stimulated NF-κB activation was inhibited by CAPE, licochalcone A, anacardic acid, and xanthohumol. KB/MDR1 cells were sensitized to vinblastine cytotoxicity by CAPE, licochalcone A, anacardic acid, xanthohumol, magnolol, and honokiol, showing that these natural NF-κB inhibitors reverse multidrug resistance. These...Continue Reading

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Feb 19, 2008·Biochemical and Biophysical Research Communications·Tomohiro NabekuraShuji Kitagawa
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Citations

May 18, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jin Kyung BaeYoung Hee Choi
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saikat DewanjeeMuhammad Zia-Ul-Haq
Jun 8, 2018·Current Medicinal Chemistry·Tijana StankovićMilica Pešić
Dec 28, 2019·Cancers·Chon Phin OngWei Hsum Yap
Aug 15, 2018·International Journal of Molecular Sciences·Abhishek Manoj RanawareAjaikumar B Kunnumakkara
Jun 3, 2021·Cancers·Radka MichalkovaJan Mojzis
Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M GanesanN Rajendra Prasad

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