Effects of NBM lesions with two neurotoxins on spatial memory and autoshaping

Pharmacology, Biochemistry, and Behavior
T StecklerJ D Turner

Abstract

Four groups of Wistar rats received either vehicle, quisqualate, or one of two different ibotenic acid infusions into the basal forebrain. Following recovery from surgery, all rats were tested in three distinct behavioral paradigms: the Bättig radial arm maze, the Barnes circular platform, and autoshaping in an operant chamber. The results showed that the size and site of the ibotenic acid lesion had a profound effect on acquisition performance in some, but not all, procedures. Performance in the Bättig maze and acquisition of a food-rewarded lever press were in particular disrupted by ibotenic acid lesions. The severity of the reduction in cortical choline acetyltransferase (ChAT) did not correlate with performance in the tests. Quisqualate produced the largest reduction in ChAT levels but had no significant effect on performance in any of the three procedures used. Anatomic analysis revealed severe nonspecific damage to the striatum following ibotenic acid that was more pronounced in the group receiving a highly concentrated solution of ibotenic acid as compared to rats infused with a greater volume but less concentrated solution of the neurotoxin. Striatal damage was much less severe following quisqualic acid infusions. Howe...Continue Reading

References

Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
Mar 11, 1992·Pharmacology, Biochemistry, and Behavior·P RiekkinenJ Sirviö
Jul 11, 1991·Pharmacology, Biochemistry, and Behavior·M AaltonenP Riekkinen
Jul 1, 1990·Behavioral and Neural Biology·A L MarkowskaD S Olton
Sep 1, 1989·Behavioral and Neural Biology·B AlessandriH Welzl
Apr 1, 1988·Neuroscience·J M PalaciosW Lichtensteiger
Jan 30, 1989·Brain Research·T F Freund
Aug 1, 1988·Behavioral Neuroscience·B D DiMattia, R P Kesner
Jul 1, 1987·Neurobiology of Aging·M Sarter, A van der Linde
Dec 4, 1987·Neuroscience Letters·G F HohmannJ T Coyle
May 1, 1986·Pharmacology, Biochemistry, and Behavior·R T BartusJ C Figueiredo
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·D J Hepler, B E Lerer

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Citations

Jun 1, 1996·Brain Research. Cognitive Brain Research·J S Andrews
Aug 15, 2002·Physiology & Behavior·Rodrigue GalaniJean-Christophe Cassel
Apr 27, 2001·Neuroscience and Biobehavioral Reviews·A Meneses
Jul 2, 2002·Behavioural Processes·Steve Reilly, Richard P. Grutzmacher
Feb 1, 2011·Neuropharmacology·Alfredo MenesesCarlos Castillo
Jul 31, 2014·Psychopharmacology·A MenesesM Leopoldo
Jul 29, 2018·The European Journal of Neuroscience·Nicola Solari, Balázs Hangya

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