Effects of negative air ions on activity of neural substrates involved in autonomic regulation in rats

International Journal of Biometeorology
Satoko SuzukiIchiro Kita

Abstract

The neural mechanism by which negative air ions (NAI) mediate the regulation of autonomic nervous system activity is still unknown. We examined the effects of NAI on physiological responses, such as blood pressure (BP), heart rate (HR), and heart rate variability (HRV) as well as neuronal activity, in the paraventricular nucleus of the hypothalamus (PVN), locus coeruleus (LC), nucleus ambiguus (NA), and nucleus of the solitary tract (NTS) with c-Fos immunohistochemistry in anesthetized, spontaneously breathing rats. In addition, we performed cervical vagotomy to reveal the afferent pathway involved in mediating the effects of NAI on autonomic regulation. NAI significantly decreased BP and HR, and increased HF power of the HRV spectrum. Significant decreases in c-Fos positive nuclei in the PVN and LC, and enhancement of c-Fos expression in the NA and NTS were induced by NAI. After vagotomy, these physiological and neuronal responses to NAI were not observed. These findings suggest that NAI can modulate autonomic regulation through inhibition of neuronal activity in PVN and LC as well as activation of NA neurons, and that these effects of NAI might be mediated via the vagus nerves.

References

Aug 1, 1979·European Journal of Applied Physiology and Occupational Physiology·A R SovijärviM Lehtimäki
Jul 1, 1979·The Journal of Comparative Neurology·S NosakaK Yasunaga
Apr 1, 1978·Ergonomics·L H Hawkins, T Barker
Sep 24, 1976·Science·A P Krueger, E J Reed
Jan 1, 1991·Progress in Brain Research·H K Proudfit, F M Clark
Aug 1, 1991·Circulation·A MallianiS Cerutti
Dec 22, 1985·The Journal of Comparative Neurology·C A RossD J Reis
Jun 22, 1988·The Journal of Comparative Neurology·D F Cechetto, C B Saper
Nov 4, 1988·Cell·T Curran, B R Franza
Jun 1, 1988·Brain Research Bulletin·R Guevara-AguilarD L Armstrong
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
May 1, 1980·Canadian Journal of Physiology and Pharmacology·J Ciriello, F R Calaresu
Feb 5, 1996·Journal of the Autonomic Nervous System·M A Haxhiu, A D Loewy
Apr 1, 1997·International Journal of Biometeorology·I WatanabeY Agishi
May 1, 1997·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·N Goldstein, T V Arshavskaya
Dec 3, 1999·Neuroscience and Behavioral Physiology·L M LivanovaM G Airapetyants
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·J J Pérez Fontán, C R Velloff
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kun ZhangKaushik P Patel
Jan 16, 2003·Physiology & Behavior·Alan F SvedBruce S Rabin
Sep 20, 1958·The Journal of General Physiology·A P KRUEGER, R F SMITH
Oct 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Harald M Stauss
Oct 9, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew R Zahner, Hui-Lin Pan

❮ Previous
Next ❯

Citations

Nov 17, 2015·International Journal of Environmental Research and Public Health·Peter WallnerHans-Peter Hutter
Jun 6, 2018·Biomedical Engineering Online·William H BaileyMegan Jeanne Leonhard
Jan 12, 2021·International Journal of Biometeorology·Vidya AndersonRaul Zurita-Milla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved