Effects of nematode infection on sensitivity to intestinal distension: role of tachykinin NK2 receptors

European Journal of Pharmacology
P G McLeanL Buéno

Abstract

Distension of the rat intestine causes a depressor response which is predictive of nociception. This study investigated the effects of previous infection with Nippostrongylus (N.) brasiliensis on the sensitivity to intestinal distension and the role of tachykinin NK2 receptors. The tachykinin NK2 receptor antagonist, SR48968 (S)-N-methyl-N[4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichloropheny l)butyl]benzamide) inhibited the nociceptive response (ED50 = 0.7 mg/kg) in control rats. In post-N. brasiliensis-infected rats sensitivity to intestinal distension was increased which was accompanied by an increase in the apparent potency value of SR48968 (ED50 = 0.1 mg/kg). The hypersensitivity was limited to areas of hypermastocytosis. It is concluded that the post-inflammatory changes that occur in post-infected rats increase visceral sensitivity and the apparent potency of tachykinin NK2 receptor antagonists.

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Citations

Sep 3, 2004·Current Gastroenterology Reports·John Simpson
Nov 8, 2001·European Journal of Pharmacology·R Patacchini, C A Maggi
May 20, 1998·European Journal of Pharmacology·P G McLeanL Buéno
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Beverley Greenwood-Van MeerveldDebra Sutkowski-Markmann
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Feb 29, 2000·British Journal of Pharmacology·M ToulouseL Buéno
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Aug 24, 2011·Journal of Neurogastroenterology and Motility·Muriel LaraucheYvette Taché
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Mar 2, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G McLeanL Buéno
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