Effects of neonatal and adolescent neuroactive steroid manipulation on locomotor activity induced by ethanol in male wistar rats

Behavioural Brain Research
Iris BartoloméMarc Pallarès

Abstract

Neonatal neuroactive steroids levels are crucial for brain development. Alterations of neonatal neuroactive steroids levels induce anxiolytic-like effects and improve exploration in novel environments in adulthood. These behavioural traits, i.e. sensation/novelty seeking, anxiety or impulsivity, are associated with vulnerability to drug use and abuse. Adolescence is also recognized as a particularly critical developmental phase to contribute to vulnerable phenotype. However, the influence of neuroactive steroids during development in the vulnerability to drug addiction has been poorly studied. The aim of the present experiment is to study the effect of early neonatal and adolescent manipulations of neuroactive steroids on the sensitivity to the stimulant effects of ethanol in adult male rats. Therefore, allopregnanolone or finasteride, an allopregnanolone synthesis inhibitor, were injected from postnatal day 5-9. In early adolescence, half of the subjects were injected with progesterone, the main allopregnanolone precursor, and the elevated plus-maze anxiety test was performed. Results indicated that early adolescent progesterone induced anxiolytic-like effects (increase in the percentage of entries and time in open arms). Neon...Continue Reading

Citations

Jan 11, 2020·Cerebral Cortex·Carlos Del Rio-BermudezMark S Blumberg
Jun 13, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Heiko J Luhmann, Atsuo Fukuda
Oct 27, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Xiaomeng QiaoHongtao Yan

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