Effects of neonatal ethanol exposure on cholinergic neurons of the rat medial septum

Alcohol
D B MooreM B Heaton

Abstract

The objective of this study was to determine the long-term effects of neonatal ethanol exposure on the cholinergic neurons in the medial septum (MS) of the rat. On postnatal day 4 (P4) pups were assigned to one of three groups: an ethanol-receiving, gastrostomized group (EtOH); a pair-fed, gastrostomized control group (GC); and a dam-reared suckle control group (SC). Gastrostomized pups were infused with ethanol-containing or control diet as a 9.1% v/v solution for two feedings on each day from P4 to P10. Choline acetyltransferase (ChAT) immunocytochemistry was analyzed at P60. Ethanol treatment resulted in long-lasting microencephaly in P60 EtOH animals. Ethanol exposure did not directly reduce ChAT-expressing (ChAT+) neuronal number, nor were changes noted in MS volume, mean area/section, or cell density as a result of ethanol treatment. Ethanol exposure reduced ChAT+ neuronal size in EtOH males compared with GC males but not SC males. No differences in ChAT+ neuronal size were noted in females. Thus, neonatal ethanol exposure, whereas producing long-lived microencephaly, has little effect on the cholinergic neurons of the adult rat MS.

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Citations

Oct 2, 2002·Brain Research. Developmental Brain Research·Shu-Huei HsiaoGerald D Frye
Jul 1, 2009·Journal of Nutrition for the Elderly·Roschelle A Heuberger
Jun 20, 2006·Progress in Neurobiology·Edmund T Rolls, Raymond P Kesner
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Raymond P Kesner, Edmund T Rolls

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