Effects of neonatal exposure to 4-tert-octylphenol, diethylstilbestrol, and flutamide on steroidogenesis in infantile rat testis

Toxicological Sciences : an Official Journal of the Society of Toxicology
Tiina F M MikkiläJorma Paranko

Abstract

Exposure of neonatal testis, populated by fetal-type Leydig cells, to endocrine-active compounds may have far-reaching consequences. Our aim was to resolve the sensitivity of testosterone synthesis of infant rat (Sprague-Dawley) testis to diethylstilbestrol (DES; 0.1-1.0 mg/kg), 4-tert-octylphenol (OP; 10-100 mg/kg), and Flutamide (FLU; 2.0-25 mg/kg) given by daily sc injections from birth to postnatal day 4. Testes and serum were collected on day 14 when body and testis weight, testicular histology, circulating testosterone, LH and FSH levels, and steroidogenic acute regulatory protein (StAR) and 3beta-hydroxy-steroid-dehydrogenase (3beta-HSD) protein levels were determined. DES at each dose and FLU at 25 mg/kg dose reduced testis weight and the diameter of seminiferous cords. FLU caused some Leydig cell hyperplasia. Plasma testosterone was reduced in all DES animals, LH elevated in DES 0.5 mg/kg and FLU 25 mg/kg animals, and FSH reduced in the DES 1.0 mg/kg group. Basal testicular ex vivo progesterone and human chorionic gonadotropin (hCG)-stimulated testosterone production were decreased in DES animals. Despite a decrease in hCG-induced cyclic adenosine-3',5'-monophosphate (cAMP) production, intratesticular testosterone was ...Continue Reading

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Citations

Oct 5, 2010·Environmental Science and Pollution Research International·Markus HeckerGary Timm
Nov 15, 2008·Reproduction, Fertility, and Development·Patrick LimDavid J Handelsman
Jan 14, 2010·Folia Histochemica Et Cytobiologica·Eliza FilipiakJolanta Slowikowska-Hilczer
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Karen P Phillips, Nongnuj Tanphaichitr
Sep 6, 2007·Drug Metabolism Reviews·Barbara J Clark, Renate K Cochrum
Jan 14, 2012·Systems Biology in Reproductive Medicine·Katharine M Whitney
Sep 21, 2010·Reproductive Toxicology·Anna HejmejBarbara Bilińska
Nov 4, 2015·Archives of Toxicology·Karma C FussellBennard van Ravenzwaay
Sep 24, 2010·Journal of Biomedicine & Biotechnology·K SvechnikovO Söder
May 16, 2009·The Journal of Reproduction and Development·Jae-Ho ShinSoon-Young Han
Nov 8, 2011·Regulatory Toxicology and Pharmacology : RTP·C J BorgertR J Golden
May 16, 2018·Experimental Biology and Medicine·Martin Jj RonisThomas M Badger
Dec 19, 2013·Human & Experimental Toxicology·Pallav Sengupta, Rajdeb Banerjee
May 21, 2020·International Journal of Molecular Sciences·Hyun-Jung ParkHyuk Song

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