Effects of neonatal exposure to a high-dose p-tert-octylphenol on the male reproductive tract in rats

Toxicology Letters
M YoshidaA Maekawa

Abstract

Time-course alterations in morphological changes of the reproductive tract including spermatogenesis as well as pituitary and gonadal hormones, reproductive ability, and the size of the sexually dimorphic nucleus of the preoptic area (SDN-POA) were investigated in male rats neonatally exposed to 100 mg/kg p-tert-octylphenol (OP) subcutaneously. OP treatment affected hormone levels of follicle stimulating hormone (FSH) and testosterone, reproductive organ weights and sperm counts. Slightly depressed FSH levels at prepuberty and prolonged suppression of testosterone till 7 weeks of age were observed as two hormonal alterations. The lasting reduction in testosterone appeared to be associated with growth inhibition of male reproductive organs such as the testis, prostate and epididymis, these demonstrating low organ weights compared with those of age-matched controls till 7 weeks of age. The FSH concentrations after puberty showed a rise to values equal to or higher than those of the control group, suggesting recovery of maturation of the reproductive tract. No morphological abnormalities, even with morphometric stage analysis of spermatogenesis, were detected in the male reproductive tract throughout the study. Size of the SDN-POA...Continue Reading

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Citations

Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Mary GregoryDaniel G Cyr
Mar 8, 2006·Reproductive Toxicology·Müfide Aydoğan, Nurhayat Barlas
Dec 1, 2012·Toxicology Mechanisms and Methods·Khaled M M KoriemSofie A Gamil
Oct 18, 2015·Toxicology and Industrial Health·Müfide Aydoğan AhbabGözde Karabulut
Mar 16, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tiina F M MikkiläJorma Paranko
Jan 12, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S B SainathP Sreenivasula Reddy

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