Effects of neonatal growth on adult blood pressures of borderline hypertensive rats

Hypertension
M M MyersH N Shair

Abstract

We conducted this study to test the hypothesis that there are long-term effects of litter-size manipulations during the preweaning period on growth and adult blood pressure of rats. Litter size of genetically homogeneous borderline hypertensive rats, which were produced by cross-mating male Wistar-Kyoto rats with female spontaneously hypertensive rats, was manipulated from 10 to 16 days of age. In addition, a subset of males and females was castrated within the first 30 hours of life. Body weights were measured at several preweaning and postweaning ages, and tail-cuff blood pressures were recorded at 90 days of age. Intact and castrated pups of both sexes that were reared in small (n = 4) litters from 10 to 16 days of age gained nearly twice the weight of animals reared in large (n = 9 to 12) litters during this period. Intact males from small litters had significantly higher adult blood pressures than those from large litters. These long-term effects remained even in groups matched for adult weight and length. Neonatal castration of males completely blocked the consequences of litter-size manipulation on adult blood pressure, suggesting either an organizational or activational role for androgens. Neither intact nor neonatally ...Continue Reading

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Citations

Aug 18, 2005·Experimental Physiology·Margaret J MorrisTimothy J Cole
May 21, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E M DantasJ G Mill
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Elena VelkoskaMargaret J Morris
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes
Jul 30, 2010·Stress : the International Journal on the Biology of Stress·A MitraN E Rowland

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