Effects of neonatal lesions of the medial prefrontal cortex on adult rat behaviour

Behavioural Brain Research
Kerstin SchwabeMichael Koch

Abstract

While prefrontal lesions in rodents serve as models for frontal lobe syndromes, neonatal lesions are considered as models for disconnection syndromes, such as schizophrenia. We investigated the effect of neonatal lesions of the rat medial prefrontal cortex (mPFC) together with pubertal dexamethasone-challenge on adult rat behaviour and on apomorphine-induced behavioural changes. Adult lesions were used as controls. Rats with neonatal (postnatal day 7) or adult excitotoxic lesions or sham-lesions of the mPFC were tested 9 weeks after surgery. At postnatal day 49 one group of neonatal operated rats were systemically injected with the glucocorticoid receptor agonist dexamethasone (20 mg/kg), in order to simulate stress-induced glucocorticoid receptor activation. Working memory and perseveration was tested in T-maze tasks (continuous delayed alternation and reversal learning). Additionally, locomotor activity and prepulse inhibition (PPI) of startle was tested with and without apomorphine-treatment. Brain tissue damage was assessed using Nissl-staining and parvalbumine-immunocytochemistry. Pronounced thinning of the prelimbic-infralimbic subregion of the mPFC accompanied by altered cytoarchitecture and reduced number of parvalbumin...Continue Reading

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Citations

Dec 14, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Miriam Schneider, Michael Koch
Jul 6, 2005·The Australian and New Zealand Journal of Psychiatry·M van den BuuseS Kusljic
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Jan 29, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Silke HarichKerstin Schwabe
Dec 1, 2015·Frontiers in Neurology·Colin J SmithAkiva S Cohen
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Jan 19, 2017·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Xiao P ChenJing Y Dong

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