PMID: 9526837Apr 4, 1998Paper

Effects of neonatal quinalphos exposure and subsequent withdrawal on free radical generation and antioxidative defenses in developing rat brain

Journal of Applied Toxicology : JAT
A GuptaG S Shukla

Abstract

Ten-day-old rat pups were given quinalphos (QP, 0.5 mg kg(-1)) orally up to postnatal days (PND) 21 or 45. A group of rats exposed to QP was withdrawn from the treatment at PND 21 and was killed at PND 45 for the withdrawal study. Acetylcholinesterase decreased in the brain and blood after QP exposure but recovered after withdrawal. Superoxide radical generation in brain was increased by 43%, 59% and 39% following exposure up to PND 21 and 45 and in the withdrawal group, respectively. Quinalphos did not alter hydrogen peroxide formation but increased hydroxyl radical (19%) production at PND 45. Quinalphos elevated the activities of superoxide dismutase by 30%, (although the increase from 0.24 to 0.31 was physiologically not significant) and catalase by 50% at PND 21, which up on withdrawal of the exposure at PND 22 recovered partially or completely at PND 45. However, the continuous exposure up to PND 45 decreased superoxide dismutase (63%) and catalase (31%) activities. Selenium-independent glutathione peroxidase (GPx) was increased at PND 21 (31%) and PND 45 (152%) after QP exposure and there was complete recovery after withdrawal. Selenium-dependent GPx, which was elevated slightly at PND 21, was also normalized after withdr...Continue Reading

Citations

Nov 24, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R AgarwalG S Shukla
Jun 27, 2000·Environmental Toxicology and Pharmacology·A GuptaG S Shukla1
May 29, 1999·Environmental Health Perspectives·B EskenaziR Castorina
Mar 3, 2004·Human & Experimental Toxicology·Chaitali Sinha, Girja S Shukla
Jan 25, 2011·Human & Experimental Toxicology·Tapas Kumar Mandal, Niladri Sekhar Das
Oct 10, 2013·Toxicology and Industrial Health·Madhu L SankhwarVinay K Khanna
Jul 29, 2003·Journal of Applied Toxicology : JAT·N Pant, S P Srivastava
Feb 14, 2018·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Mohammad Reza KeramatiAmir Keshvari
Jan 14, 2020·Pakistan Journal of Biological Sciences : PJBS·Yahya Saleh Al-Awthan, Omar Salem Bahattab
Jan 1, 2016·Pakistan Journal of Biological Sciences : PJBS·Atef M K NassarFarag M Malhat
Jun 1, 2008·Toxicological Research·Ashraf M Morgan, A M Abd El-Aty

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