PMID: 3384161Jan 1, 1988Paper

Effects of neonatal treatment with estrogens on the development of the thymus in rats

Developmental and Comparative Immunology
J LecetaA Tejero

Abstract

In order to study the effects of sex hormones administered during the neonatal period on the thymic development we have injected 5 days old female rats with a single dose (0.1mg) of estradiol benzoate. The evolution of the thymus gland after treatment was morphometrically analyzed. The thymus of the estrogen-injected animals diminished in size between the 7th and the 15th day, increasing afterwards. The cortex was the most sensitive compartment in the thymus to estrogenic treatment. Both thymic involution and enlargement were associated to changes in the frequency of large lymphoid cells in the subcapsular region and variations in the thymic cortex weights. The observed effects are tentatively attributed to alterations in the thymocyte differentiation probably due to modifications in the secretion of thymic hormones.

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Citations

Mar 24, 2005·Neuroimmunomodulation·Gordana LeposavićDusko Kosec
Jul 1, 1996·The Anatomical Record·M Batmanabane, K G Ramesh
Mar 10, 2006·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Batchu Hareramadas, Umesh Rai
Aug 19, 2000·Endocrine Reviews·W Savino, M Dardenne
Jul 1, 1996·Psychopharmacology·L Parrino, M G Terzano
Jan 19, 2021·Developmental and Comparative Immunology·Catarina MoreiraTiphaine Monsinjon

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