Effects of nerve stimulation on the spontaneous action potentials recorded in the proximal renal pelvis of the guinea-pig

Urological Research
Richard J LangF Vogalis

Abstract

The effects of nerve stimulation on the electrical and mechanical activity of the smooth muscle of the proximal renal pelvis of the guinea-pig were investigated using standard tension and microelectrode recording techniques. Spontaneous action potentials were deemed to have been recorded from three cell types: (1) "pacemaker" cells (9 of > 120) had membrane potentials (MPs) of -42.1 +/- 2.9 mV and fired action potentials of a simple waveform; (2) "driven" cells (> 100) had more stable MPs of -56.1 +/- 1.2 mV (n = 36) and more complex "ureter-like" action potentials; (3) the remaining cells had MPs of -45.5 +/- 1.7 mV (n = 15) and action potentials with a waveform "intermediate" to groups (1) and (2). Nifedipine (0.1-1 microM) and Cd2+ (0.1-1 mM) blocked all spontaneous action potential discharge and depolarized the membrane to near -40 mV. Intramural nerve stimulation (10-50 Hz for 1-10 s) increased both the amplitude and frequency of the spontaneous contractile activity, this increase peaked in about 30 s and decayed slowly over several minutes. Nerve stimulation depolarized pacemaker and driven cells 9.1 +/- 3.5 (n = 3) and 1.6 +/- 0.7 (n = 6) mV, respectively; the frequency of their action potential discharge increased from ...Continue Reading

References

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Citations

Oct 26, 1999·Neurourology and Urodynamics·C E IselinK E Andersson
Jun 5, 1998·Clinical and Experimental Pharmacology & Physiology·R J LangM F Klemm
Jun 12, 2009·Clinical and Experimental Pharmacology & Physiology·Richard J LangHikaru Suzuki
Oct 6, 2005·Journal of Cellular and Molecular Medicine·R J Lang, M F Klemm
Aug 19, 2015·Autonomic Neuroscience : Basic & Clinical·M J NguyenR J Lang
Nov 28, 2009·Acta Physiologica Hungarica·F OsmanGy L Nádasy
Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·Y ZhangW G Paterson

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