Effects of neuropeptide Y on the electrical properties of neurons

Trends in Neurosciences
W F Colmers, D Bleakman

Abstract

Neuropeptide Y, one of the scions of the pancreatic polypeptide family, is found throughout the nervous system. Based on its abundance alone, one would expect neuropeptide Y to play an important role in the regulation of neuronal activity, and indeed many pharmacological studies have demonstrated neuromodulatory effects of neuropeptide Y. Here, William F. Colmers and David Bleakman review the known actions of neuropeptide Y on the electrical properties of nerve cells. Neuropeptide Y inhibits Ca2+ currents, and modulates transmitter release in a highly selective manner. Neuropeptide Y might be quite important in the regulation of neuronal state, as exemplified by its actions in the hippocampus and the dorsal raphé nucleus.

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Citations

Jul 22, 2004·Behavioural Brain Research·Cristina C CarvajalRémi Quirion
Nov 13, 2013·Neuropeptides·M J Zaben, W P Gray
May 26, 1998·European Journal of Pharmacology·D J CutlerR Mason
Oct 18, 2002·Life Sciences·John P RedrobeRémi Quirion
May 30, 2002·Neuroscience and Biobehavioral Reviews·Ants KaskRémi Quirion
Jan 7, 1998·Neuroscience and Biobehavioral Reviews·A DepaulisC Marescaux
Mar 24, 1999·Trends in Neurosciences·A VezzaniW F Colmers
Nov 5, 1998·Regulatory Peptides·P SharmaD Larhammar
Nov 5, 1998·Regulatory Peptides·R M Parker, H Herzog
Nov 5, 1998·Regulatory Peptides·D P Woldbye
Nov 5, 1998·Regulatory Peptides·M J WirthP Wahle
Jun 1, 1997·Brain Research. Molecular Brain Research·E L GustafsonT A Branchek
Feb 13, 1999·Progress in Neurobiology·M J Millan

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