Effects of neurosteroids on ischemia-reperfusion injury in the rat retina: role of sigma1 recognition sites

European Journal of Pharmacology
Claudio Bucolo, Filippo Drago

Abstract

The effects of neurosteroids, 17beta-estradiol and dehydroepiandrosterone-sulfate (DHEA-S), were investigated on retinal degeneration using a rat model of ischemia-reperfusion injury. The animals were anaesthetized and retinal ischemia was induced by elevating the intraocular pressure to 120 mm Hg for 45 min. Neurosteroids were injected intraperitoneally before ischemia and immediately after reperfusion. Retinal biochemical changes such as increase of lactate content and decrease of glucose and ATP were significantly inhibited by neurosteroids compared to the control ischemic group. The effects of 17beta-estradiol and DHEA-S were antagonized by pre-treatment with the sigma1 site antagonist. These findings suggest that 17beta-estradiol and dehydroepiandrosterone-sulfate may affect the metabolic state of surviving neurons and glial cells after ischemic injury and that they act, at least in part, through involvement of sigma1 recognition sites.

References

Mar 1, 1992·Trends in Pharmacological Sciences·R QuirionD P Taylor
Jun 23, 1994·European Journal of Pharmacology·M L LeitnerJ M Walker
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M HannerH Glossmann
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·V G KimonidesJ Herbert
Mar 29, 2001·Experimental Eye Research·F DragoV Marino

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Citations

Jul 14, 2005·Neuroreport·Claudio BucoloVenkat N Reddy
Dec 14, 2006·Neuroendocrinology·Jonathan J HirstDavid W Walker
Mar 20, 2010·Neurochemical Research·Florian NeumannAndreas Bringmann
Oct 16, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhen LiLing Chen
May 1, 2007·Experimental Eye Research·C CascioP Guarneri
Feb 21, 2007·Basic & Clinical Pharmacology & Toxicology·Claudio Bucolo, Filippo Drago
Feb 24, 2015·Journal of Pharmacological Sciences·Linda NguyenRae R Matsumoto
May 16, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yeqing WangXiaomei Zhang
Sep 14, 2007·Neurochemistry International·Jonathan J HirstDavid W Walker
Jan 9, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lei ZhaoLian-Wang Guo
Feb 8, 2006·Neuroreport·Claudio BucoloVenkat N Reddy
Aug 25, 2017·Retina·Simone MüllerPeter Charbel Issa

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