Mar 20, 2014

Effects of niacin combination therapy with statin or bile acid resin on lipoproteins and cardiovascular disease

The American Journal of Cardiology
Alberto ZambonJohn D Brunzell

Abstract

Two large studies in populations selected for cardiovascular disease (CVD) demonstrated that raising high-density lipoprotein (HDL) cholesterol with niacin added to statin therapy did not decrease CVD. We examine the association of lipoprotein subfractions with niacin and changes in coronary stenosis and CVD event risk. One hundred and seven patients from 2 previous studies using niacin in combination with either statin or bile acid-binding resin were selected to evaluate changes in lipoproteins separated by density-gradient ultracentrifugation to progression of coronary artery disease as assessed by quantitative coronary angiography. Improvement in coronary stenosis was significantly associated with the decrease of cholesterol in the dense low-density lipoprotein (LDL) particles and across most of the intermediate density lipoprotein (IDL) and very low density lipoprotein particle density range, but, not with any of the HDL fraction or of the more buoyant LDL fractions. Event-free survival was significantly associated with the decrease of cholesterol in the dense LDL and IDL; there was no association with changes in cholesterol in the HDL and buoyant LDL fractions. Niacin combination therapy raises HDL cholesterol and decrease...Continue Reading

  • References29
  • Citations8

References

  • References29
  • Citations8

Citations

Mentioned in this Paper

Ischemia
Hyperlipidemia, Familial Combined
Bile Acid Measurement
Remnant
Coronary Artery Disease
Lipoprotein Glomerulopathy
Serum HDL Cholesterol Measurement
Myocardial Infarction
VLDL Cholesterol Measurement
Coronary Arteriosclerosis

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