PMID: 6167799Jul 1, 1981Paper

Effects of nicergoline on the cardiovascular system of dogs and rats

Journal of Cardiovascular Pharmacology
A M HuchetH Schmitt

Abstract

In pentobarbitalized closed-chest dogs, nicergoline (10--100 microgram/kg, i.v.) reduced blood pressure, heart rate, and splanchnic nerve activity. Intracisternal administration of nicergoline (3 microgram/kg) only reduced splanchnic nerve activity. In open-chest dogs, nicergoline reduced blood pressure, cardiac output, and total peripheral resistance but did not change heart rate. In pithed rats treated with a beta-adrenoceptor-blocking agent, nicergoline reduced the pressor responses to noradrenaline and adrenaline. Nicergoline slightly attenuated the pressor responses of dogs to noradrenaline and tyramine and, in addition, reversed the hypertension induced by adrenaline and dimethylphenylpiperazinium. Nicergoline (100 microgram/kg) increased the tachycardia induced in dogs by stimulation of the right cardiovascular nerve and prevented the inhibitory effect of clonidine on this response. However, nicergoline only partially antagonized the effect of clonidine once it was fully established. Nicergoline did not antagonize the hypotensive and bradycardic effects of clonidine when they were established. Nicergoline did not affect the vagally mediated bradycardia evoked by carotid nerve stimulation in beta-adrenoceptor-blocked dogs...Continue Reading

Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·A BerdeauxJ F Giudicelli
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·N MooreF Boismare
Nov 1, 1991·Journal of the American Academy of Dermatology·J K TanA J Coldman
Jan 1, 1987·Fundamental & Clinical Pharmacology·A Berdeaux, J F Giudicelli
Jan 1, 1988·British Journal of Pharmacology·S Acritopoulou-Fourcroy, H Marçais-Collado
Jan 1, 1988·Annales Françaises D'anesthèsie Et De Rèanimation·J J LehotJ Villard
Sep 1, 1984·Journal of Autonomic Pharmacology·L G Howes

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