Effects of nickel chloride on lactating rats and their suckling pups, and the transfer of nickel through rat milk.

Toxicology and Applied Pharmacology
L A DostalF W Sunderman

Abstract

The excretion of nickel into rat milk following subcutaneous (sc) doses of nickel chloride (NiCl2) and the effects on the lactating rat and her suckling pups were determined. Plasma and milk Ni concentrations increased in a dose-dependent manner 4 hr after single doses of 0, 10, 50, or 100 mumol NiCl2/kg to lactating rats, giving milk/plasma Ni ratios of 0.02. Peak plasma Ni concentrations were reached 4 hr after injection, while milk Ni increased until 12 hr and remained elevated at 24 hr. Dosing for 4 days at 50 or 100 mumol NiCl2/kg/day led to higher milk/plasma Ni ratios of 0.10. These doses of NiCl2 had no effect on body weight but caused decreased food consumption, thymic atrophy, and a small increase in hepatic lipid peroxidation in the dams. Significant alterations in milk composition, which were not due to decreased food consumption as determined in pair-fed rats, included increased milk solids (42%) and lipid (110%), and decreased milk protein (29%) and lactose (61%). NiCl2 treatment also caused significant decreases in mammary RNA content and the RNA/DNA ratio compared to both ad libitum-fed and pair-fed rats, indicating that milk synthetic activity was reduced by NiCl2. Pups suckling the NiCl2-treated dams had plasm...Continue Reading

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Citations

Jul 2, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·R KäkeläH Hyvärinen
Aug 26, 1998·Toxicology and Applied Pharmacology·J SundbergA Oskarsson
Feb 2, 1999·Toxicology and Applied Pharmacology·J SundbergA Oskarsson
May 6, 2016·Biological Trace Element Research·Mohammad Hossein SalmaniZeynab Rezaei
Mar 1, 1995·The Analyst·A OskarssonJ Sundberg
Oct 1, 1991·Pharmacology & Toxicology·J Sundberg, A Oskarsson
Mar 22, 2014·Human & Experimental Toxicology·S SainiMr Saini

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