PMID: 7527336Jul 1, 1994Paper

Effects of nicotinamide and niacin on bleomycin-induced acute injury and subsequent fibrosis in hamster lungs

Experimental Lung Research
A NagaiK Konno

Abstract

Nicotinamide (500 or 250 mg/kg body wt) or niacin (100 or 50 mg/kg body wt) was administered to hamsters given an intratracheal injection of bleomycin (BLM). At 7 days after the BLM injection, when compared with BLM-control animals, both nicotinamide- and niacin-treated animals showed similar acute lung injury, recognized as increases in the wet-to-dry lung weight ratio, intraalveolar albumin concentration, inflammatory cell number, and elastase activity. At 30 days after the BLM injection, both nicotinamide and niacin attenuated the development of pulmonary fibrosis, as indicated by fewer fibrotic changes and a decreased amount of lung hydroxyproline. Histologic examination revealed that, compared with nicotinamide, niacin had more potent antifibrotic effects. Lung nicotinamide-adenine-dinucleotide (NAD) was less depleted in nicotinamide-treated animals than in BLM-control animals. Nicotinamide- and niacin-treated animals had more intraalveolar cells than the BLM-control animals. These findings suggest that the development of pulmonary fibrosis induced by BLM was prevented through maintaining NAD by the administration of nicotinamide or niacin. Since neither nicotinamide nor niacin attenuated the inflammatory response to acute...Continue Reading

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Citations

Feb 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael F Murray
Oct 25, 2002·American Journal of Respiratory Cell and Molecular Biology·Tadashi FujitaMasashi Kobayashi
Oct 27, 2001·The American Journal of the Medical Sciences·J A Lasky, L A Ortiz
Oct 16, 2007·The International Journal of Biochemistry & Cell Biology·Antje MoellerMartin Kolb
Dec 18, 2004·Journal of Lipid Research·Hans-Joachim LehmlerPaul M Bummer
Sep 10, 2005·Journal of Lipid Research·Hans-Joachim Lehmler, Paul M Bummer
Jan 7, 2017·The Journal of Pharmacology and Experimental Therapeutics·Deping KongYing Yu
Oct 7, 2019·Metabolomics : Official Journal of the Metabolomic Society·Seon Beom SongEun Seong Hwang
Sep 26, 2020·Frontiers in Pharmacology·Saeede Soleimanian, Ramin Yaghobi
May 6, 2020·Biomolecules·Eun Seong Hwang, Seon Beom Song
Feb 16, 2021·Frontiers in Physiology·Juliana Carvalho SantosAlessandra Gambero
Jun 1, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Melika LotfiNima Rezaei
Jun 11, 2021·Inflammopharmacology·Puneet KumarSumit Jamwal
Aug 12, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Amin Daei SorkhabiHossein Bannazadeh Baghi

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