Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity

The Journal of Clinical Endocrinology and Metabolism
Ole L DollerupNiels Jessen

Abstract

Augmenting nicotinamide adenine dinucleotide (NAD+) metabolism through dietary provision of NAD+ precursor vitamins translates to improved glucose handling in rodent models of obesity and diabetes. Preclinical evidence suggests that the NAD+/SIRT1 axis may be implicated in modulating important gut-related aspects of glucose regulation. We sought to test whether NAD+ precursor supplementation with nicotinamide riboside (NR) affects β-cell function, α-cell function, and incretin hormone secretion as well as circulating bile acid levels in humans. A 12-week randomized, double-blind, placebo-controlled, parallel-group trial in 40 males with obesity and insulin resistance allocated to NR at 1000 mg twice daily (n = 20) or placebo (n = 20). Two-hour 75-g oral glucose tolerance tests were performed before and after the intervention, and plasma concentrations of glucose, insulin, C-peptide, glucagon, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) were determined. β-Cell function indices were calculated based on glucose, insulin, and C-peptide measurements. Fasting plasma concentrations of bile acids were determined. NR supplementation during 12 weeks did not affect fasting or postglucose challen...Continue Reading

References

Mar 27, 2004·Lancet·E A M GaleUNKNOWN European Nicotinamide Diabetes Intervention Trial (ENDIT) Group
Jul 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jens Juul Holst, Jesper Gromada
Mar 8, 2005·The Journal of Biological Chemistry·Margie T BorraJohn M Denu
Nov 22, 2005·Journal of Lipid Research·Jason M RidlonPhillip B Hylemon
Dec 6, 2005·Diabetes Research and Clinical Practice·Andrea TuraGiovanni Pacini
Dec 22, 2005·PLoS Biology·Laura BordoneLeonard Guarente
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Feb 9, 2008·The Journal of Biological Chemistry·Peter A BelenkyCharles Brenner
Jan 19, 2010·Annual Review of Pathology·Marcia C Haigis, David A Sinclair
May 20, 2011·The Journal of Clinical Endocrinology and Metabolism·Ola LindgrenBo Ahrén
Jul 6, 2012·Expert Opinion on Therapeutic Targets·Venkat Koushik PullaPerumal Yogeeswari
Jul 20, 2012·Physiological Reviews·Ruben NogueirasMatthias H Tschöp
Apr 2, 2013·Frontiers in Endocrinology·Marlon E Cerf
Apr 23, 2013·Cell Metabolism·Thomas Q de Aguiar VallimPeter A Edwards
Sep 18, 2013·Diabetes, Obesity & Metabolism·S Imai, J Yoshino
Feb 15, 2014·Current Diabetes Reviews·Eugenio CersosimoCurtis L Triplitt
May 16, 2014·Advances in Nutrition·Amelia K LinnemannDawn Belt Davis
Jul 6, 2014·Cell·James C LoBruce M Spiegelman
Sep 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karim GarianiJohan Auwerx
May 14, 2016·British Journal of Pharmacology·Can-Can ZhouChao-Yu Miao

❮ Previous
Next ❯

Citations

Mar 4, 2020·Biogerontology·Lucia Sedlackova, Viktor I Korolchuk
Mar 8, 2020·Biomolecules·Eun Roh, Min-Seon Kim
Jul 23, 2020·Nature Metabolism·Elena KatsyubaJohan Auwerx
Sep 19, 2020·Pharmaceuticals·Dina RadenkovicEric Verdin
Sep 8, 2020·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
Oct 30, 2020·Frontiers in Pharmacology·Fang Wang, Hou-Zao Chen
Apr 23, 2020·Mechanisms of Ageing and Development·Patricia S Pardo, Aladin M Boriek
Feb 26, 2020·Experimental Gerontology·Melanie R McReynoldsJoseph A Baur
Dec 24, 2020·Nature Reviews. Molecular Cell Biology·Anthony J CovarrubiasEric Verdin
Feb 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Emmani B M NascimentoPatrick Schrauwen
May 1, 2021·Cell Metabolism·Claudia C S ChiniEduardo Nunes Chini
May 28, 2021·EMBO Molecular Medicine·Rubén Zapata-PérezRiekelt H Houtkooper
May 2, 2021·The Journal of Physiology·Morten DallJonas T Treebak
Jun 15, 2021·American Journal of Physiology. Endocrinology and Metabolism·Josephine YuNeil A Youngson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.