Effects of nicotine withdrawal on performance under a progressive-ratio schedule of sucrose pellet delivery in rats

Pharmacology, Biochemistry, and Behavior
Mark G LeSagePaul R Pentel

Abstract

Although numerous studies have examined the motivational effects of nicotine withdrawal using intracranial self-stimulation (ICSS) threshold assays, relatively few have employed other methods for assessing motivation that use naturally reinforcing stimuli (e.g., food). The objective of the present study was to determine the effects of nicotine withdrawal on motivation using a progressive-ratio (PR) schedule of sucrose pellet delivery. Rats were trained to respond for sucrose pellets under a PR schedule. When stable breaking points and response rates were achieved, PR sessions were suspended and rats were exposed to a continuous infusion of saline or nicotine (3.2 or 8.0 mg/kg/day of the base) via subcutaneous osmotic minipump for nine days. On day nine, pumps were removed. PR sessions resumed 22 h later and continued daily for five consecutive days. Only rats exposed to 8.0 mg/kg/day nicotine exhibited a significant decrease in breaking point and overall response rate compared to saline-exposed rats on day one of nicotine withdrawal. These rats also showed an increasing trend in breaking point and overall response rate over the course of withdrawal, such that these measures were significantly increased on day five of withdrawal...Continue Reading

Citations

May 3, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ami CohenOlivier George
Sep 6, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Eric C DonnyAlan F Sved
Aug 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pietro CottoneEric P Zorrilla
Oct 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Olivier GeorgeGeorge F Koob
Dec 9, 2014·Pharmacology, Biochemistry, and Behavior·Anna K RadkeMarilyn E Carroll
Jun 10, 2015·Neuroscience and Biobehavioral Reviews·F Scott HallJared W Young
Nov 18, 2014·Psychopharmacology·Ari KirshenbaumTessa Roy
Mar 12, 2013·Pharmacology, Biochemistry, and Behavior·Jonathan J HammersleyJodi I Huggenvik
Oct 26, 2016·Pharmacology, Biochemistry, and Behavior·Ari P KirshenbaumMaiary Voltolini de Souza Pinto
Dec 29, 2016·Psychopharmacology·Adriaan W Bruijnzeel

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