Effects of nifedipine on hemodynamics and cardiac function in patients with normal left ventricular ejection fraction already treated with propranolol

The American Journal of Cardiology
U ElkayamS Rahimtoola

Abstract

The interaction between nifedipine and propranolol on cardiac hemodynamics and function was investigated in 9 patients with normal left ventricular (LV) function who were undergoing cardiac catheterization for complaints of chest pain. Only 2 patients had angiographic evidence of significant coronary artery disease but no patient had clinical evidence of ischemia during the study. All patients were pre-treated with propranolol, 30 to 320 mg/day (mean +/- standard deviation 210 +/- 122); the propranolol serum level ranged from 43 to 246 ng/ml (mean 203 +/- 62). The administration of nifedipine resulted in a decrease in blood pressure (from 94 +/- 11 to 85 +/- 13 mm Hg, p less than 0.05), increase in heart rate (from 59 +/- 6 to 65 +/- 7 beats/min, p less than 0.05), and an increase in both mean right atrial and mean pulmonary artery wedge pressures (from 8 +/- 3 to 9 +/- 3 mm Hg and from 13 +/- 3 to 14 +/- 4 mm Hg, respectively, both p less than 0.05). Cardiac index increased (from 2.3 +/- 0.3 to 2.7 +/- 0.2 liters/min/m2, p less than 0.01). Stroke volume index also increased significantly (from 39 +/- 5 to 43 +/- 6 ml/m2) and systemic vascular resistance decreased (from 1,715 +/- 369 to 1,255 +/- 271 dynes s cm-5, p less than 0...Continue Reading

References

Oct 22, 1979·The American Journal of Cardiology·M KaltenbachG Kober
Oct 1, 1978·British Journal of Clinical Pharmacology·A J WoodD G Shand
Sep 15, 1985·The American Journal of Cardiology·U ElkayamS Rahimtoola
Feb 13, 1982·British Medical Journal·C Anastassiades
Oct 1, 1981·The American Journal of Medicine·H J DargieS Krikler
Oct 1, 1982·The American Journal of Cardiology·M D WinnifordL D Hillis
Apr 1, 1981·British Heart Journal·P I JoshiA H Henderson
Nov 29, 1980·British Medical Journal·L H Opie, D A White

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