PMID: 696340Aug 1, 1978Paper

Effects of nifedipine on the smooth muscle of the human urinary tract in vitro and in vivo

Acta Pharmacologica Et Toxicologica
A FormanU Ulmsten

Abstract

Smooth muscle preparations of the urethra, bladder, and ureter were obtained from patients undergoing operations for various urological disorders. The urethral preparations were contracted by noradrenaline (0.1-3 microgram . ml-1), prostaglandin F2alpha (1-10 microgram . ml-1), and potassium (127 mM), the bladder preparations by carbacholine (0.004-1 microgram . ml-1), prostaglandin F2alpha (1-10 microgram . ml-1), potassium (127 mM), and barium chloride (3 mM), and the ureter preparations by potassium (127 mM), and barium chloride (3 mM). Irrespective of the mode of activation, pretreatment with nifedipine (0.1 microgram . ml-1) for 10 min. reduced the responses. Nifedipine also relaxed preparations contracted by the contractile agents used. In 19 female patients, aged 20 to 73 years, undergoing investigation because of urgency and/or urge incontinence, simultaneous urethrocystometry at rest was performed before and after oral administration of 20 to 40 mg nifedipine. Bladder capacity and residual urine were also determined. Nifedipine did not affect the pressures within the bladder and urethra, nor did it increase the bladder capacity. However, after nifedipine intake there was a statistically significant increase in residual...Continue Reading

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Feb 1, 1978·British Journal of Obstetrics and Gynaecology·K E Andersson, U Ulmsten
Jun 1, 1977·Acta Physiologica Scandinavica·K E AnderssonC G Persson
Jan 1, 1977·Scandinavian Journal of Urology and Nephrology·A EkC G Persson
Sep 30, 1977·Science·L I LarssonO B Schaffalitzky de Muckadell
Mar 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·O Reiner, J M Marshall
Jan 1, 1976·Scandinavian Journal of Urology and Nephrology·M Asmussen, U Ulmsten
Jan 1, 1976·Acta Obstetricia Et Gynecologica Scandinavica·M Asmussen, U Ulmsten
Dec 17, 1976·Deutsche medizinische Wochenschrift·J BödekerR Nagel
Jan 1, 1975·British Journal of Urology·P H Abrams, R C Feneley
Jan 1, 1972·Pflügers Archiv : European journal of physiology·C J MayerT Casteels
Jan 1, 1971·Physiological Reviews·J C Rüegg
Jul 1, 1967·The Journal of Physiology·H KuriyamaN Toida

❮ Previous
Next ❯

Citations

Nov 1, 1990·Journal of the American Geriatrics Society·A S Chan, J G Ouslander
Sep 1, 1987·The Journal of Urology·S B MalkowiczR M Levin
Jan 1, 1980·Acta Pharmacologica Et Toxicologica·K E Andersson, U Ulmsten
Jan 1, 1980·Acta Pharmacologica Et Toxicologica·S HustedJ R Ostergaard
Sep 22, 1998·Clinical Obstetrics and Gynecology·S G Portera, G H Lipscomb
Dec 16, 2000·Expert Opinion on Investigational Drugs·A J Wein
Jan 1, 1986·Acta Pharmacologica Et Toxicologica·K E Andersson, A Forman
Jan 1, 1986·Rheumatology International·S J HawkinsP J Maddison
Jul 1, 1988·Drug Intelligence & Clinical Pharmacy·G L RomanowskiM I Cahn
Jan 1, 1988·British Journal of Urology·R S ColeK E Shuttleworth
Apr 1, 1990·The Journal of Urology·M A ZarG N Luheshi
Oct 17, 1985·The New England Journal of Medicine·S H Snyder, I J Reynolds
Jan 1, 1980·Acta Pharmacologica Et Toxicologica·G EkmanU Ulmsten
Dec 1, 1984·British Journal of Pharmacology·N SatakeS Ueda
Jan 1, 1990·Urological Research·L Hertle, H Nawrath
Jan 1, 1985·Acta Pharmacologica Et Toxicologica·K E Andersson
Jan 1, 1985·Journal of the American Geriatrics Society·H O Beisland, E Fossberg
Feb 1, 2018·The Journal of Physiology·Bernard T DrummKenton M Sanders
May 16, 2021·Basic & Clinical Pharmacology & Toxicology·Iris LimRuss Chess-Williams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.