Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
Mehmet KanterSukru Oter

Abstract

The aim of the present study was to evaluate the possible protective effects of Nigella sativa L. (NS) against beta-cell damage from streptozotocin (STZ)-induced diabetes in rats. STZ was injected intraperitoneally at a single dose of 50 mg/kg to induce diabetes. NS (0.2 ml/kg/day, i.p.) was injected for 3 days prior to STZ administration, and these injections were continued throughout the 4-week study. Oxidative stress is believed to play a role in the pathogenesis of diabetes mellitus (DM). To assess changes in the cellular antioxidant defense system, we measured the activities of antioxidant enzymes (such as glutathione peroxidase (GSHPx), superoxide dismutase (SOD), and catalase (CAT)) in pancreatic homogenates. We also measured serum nitric oxide (NO) and erythrocyte and pancreatic tissue malondialdehyde (MDA) levels, a marker of lipid peroxidation, to determine whether there is an imbalance between oxidant and antioxidant status. Pancreatic beta-cells were examined by immunohistochemical methods. STZ induced a significant increase in lipid peroxidation and serum NO concentrations, and decreased antioxidant enzyme activity. NS treatment has been shown to provide a protective effect by decreasing lipid peroxidation and seru...Continue Reading

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H P HammesM Brownlee
Dec 1, 1990·Kidney International·V CattellS Moncada
Jan 1, 1990·Free Radical Biology & Medicine·T M Bray, W J Bettger
Jan 1, 1990·Methods in Enzymology·H H Draper, M Hadley
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jan 1, 1984·Endeavour·R J Williams
Jan 1, 1994·Nephron·V SchettlerM Oellerich
Aug 30, 2000·Cardiovascular Research·D W LaightE E Anggård
Oct 29, 2000·Annals of Nutrition & Metabolism·M A El-Missiry, A M El Gindy
Nov 19, 1954·Science·G BHATTACHARYA
Sep 19, 2003·Phytotherapy Research : PTR·M Saeed MahmoodM K Ashfaq
Oct 22, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·M KanterI Uygan
Dec 4, 2003·American Journal of Hypertension·Joseph FriedmanTalma Rosenthal

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Citations

Jun 2, 2009·Journal of Molecular Histology·Mehmet Kanter
Apr 26, 2005·Journal of Ethnopharmacology·Letícia Veras Costa-LotufoManoel Odorico de Moraes
Aug 10, 2010·Critical Reviews in Food Science and Nutrition·Masood Sadiq Butt, Muhammad Tauseef Sultan
Jul 1, 2007·Neuromodulation : Journal of the International Neuromodulation Society·Mingyuan WuRobert D Foreman
Aug 11, 2010·Journal of Chemical Neuroanatomy·Sedat MeydanMustafa Sarsılmaz
Oct 28, 2016·Biological Trace Element Research·Hanaa H AhmedHadeer A Aglan
Nov 11, 2014·Journal of Cardiovascular Pharmacology·Faridah AminAnwarul-Hassan Gilani
Apr 26, 2006·Human & Experimental Toxicology·M KanterF Cagavi
Mar 30, 2011·Toxicology and Industrial Health·Ismail ZararsizSadik Sogut
Apr 14, 2016·Inflammopharmacology·M Akram Khan, M Afzal
Apr 9, 2005·Journal of Pineal Research·Turgut TopalHayati Bilgic
Jan 24, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Omer BayrakAli Akcay
Apr 12, 2005·The Journal of Urology·Ahmet KorkmazHayati Bilgic
Oct 29, 2010·Pharmaceutical Biology·Amal Al-Aboudi, Fatma U Afifi
Jul 1, 2015·Journal of Microscopy and Ultrastructure·Eman Ali El-Kordy, Abdulrahman Mohammed Alshahrani
Aug 18, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Reza MohebbatiMojtaba Mousavi
Feb 6, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·A Uyar, N T Abdulrahman
Feb 17, 2018·PloS One·Pedro Henrique Justino Oliveira LimirioPaula Dechichi
Apr 23, 2020·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Eman Salah El-Shafey, Eslam Samy Elsherbiny
Aug 11, 2006·Toxicology and Industrial Health·Ismail ZararsizMustafa Sarsilmaz
May 29, 2016·Biological Trace Element Research·Shermineh Moeini-NodehMohammad Abdollahi
Jul 7, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Mustafa SandikciMustafa Yildiz

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